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Anti-Calreticulin Segregates Anti-Ro Sera in Systemic Lupus Erythematosus: Anti-Calreticulin Is Present in Sera with Anti-Ro Alone But Not in Anti-Ro Sera with Anti-La or Anti-RibonucleoproteinR. HAL SCOFIELD, DOINA M. RACILA, TOM P. GORDON, BIJI T. KURIEN, and RICHARD D. SONTHEIMER
ABSTRACT. Methods. The sera of 77 patients with SLE were studied by immunodiffusion, solid phase immunoassay, and immunoblot for antibodies against ribonucleoprotein (RNP) autoantigens and calreticulin. Results. Thirty-five had anti-calreticulin and 40 had anti-60 kDa Ro. There was no association of anti-60 kDa Ro and anti-calreticulin. However, among anti-60 kDa Ro positive sera that also contained either anti-La or anti-RNP, none of 18 had anti-calreticulin. All the remaining sera with anti-60 kDa Ro had anti-calreticulin and anti-52 kDa Ro.
Conclusion.
Anti-60 kDa Ro patients with SLE can be divided into those with anti-60 kDa Ro and either anti-La or anti-RNP or those with anti-60 kDa Ro, anti-52 kDa Ro, and anti-calreticulin.
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