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No Association of Vitamin D Receptor Gene Start Codon Fok I Polymorphisms in Chinese Patients with Systemic Lupus Erythematosus
CHUNG-MING HUANG, MEI-CHEN WU, JER-YUARN WU, and FUU-JEN TSAI
ABSTRACT.
Methods. A control group of 90 healthy people and 52 patients with SLE were examined. Using polymerase chain reaction (PCR) based restriction analysis, we evaluated the relationship between Fok I polymorphisms and SLE, where an unexcisable length was determined to be 265 bp (FF), and the 2 fragments measuring 169 bp and 96 bp were determined to be excisable lengths (ff). Results. For the genotype of VDR Fok I start codon polymorphism, there were no statistically significant differences between the 2 groups (chi-squared test, p = 0.07). Additionally, we did not detect any association of VDR genotype with the clinical and laboratory profiles in SLE patients. Conclusion. Our results suggest that the vitamin D receptor Fok I start codon polymorphism is not related to patients with SLE in Taiwan. (J Rheumatol 2002;29:1211-3) Key Indexing Terms:
VITAMIN D RECEPTOR POLYMORPHISM
From the Division of Immunology and Rheumatology, Department of Internal Medicine, and Department of Medical Genetics, China Medical College Hospital, Taichung, Taiwan, ROC. Supported by a grant from China Medical College Hospital. C-M. Huang, MD, Department of Immunology and Rheumatology; M-C. Wu, Associate Researcher; J-Y. Wu, PhD, Associate Professor; F-J. Tsai, MD, PhD, Department of Medical Genetics. Address reprint requests to Dr. F-J. Tsai, Department of Medical Genetics, China Medical College Hospital, No. 2 Yuh Der Road, Taichung, Taiwan, ROC. E-mail: d0704@www.cmch.org.tw Submitted May 23, 2001; revision accepted December 7, 2001.
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