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Magnetic Resonance Imaging Criteria for Distinguishing Between Inclusion Body Myositis
and Polymyositis
ELISABETH DION, PATRICK CHERIN, CHRISTINE PAYAN, JEAN-CHARLES FOURNET, THOMAS PAPO, THIERRY MAISONOBE, ERIC AUBERTON, OLIVIER CHOSIDOW, PIERRE GODEAU, JEAN-CHARLES PIETTE, SERGE HERSON, and PHILIPPE GRENIER
ABSTRACT.
Methods. We investigated 220 patients with suspected inflammatory myopathies by magnetic resonance imaging (MRI). Findings were compared with the results of clinical and biological examinations and muscle biopsy. PM and IBM were diagnosed in 25 patients each. Quantitative and qualitative MRI analysis of the 3 muscle groups of the 2 thighs included fatty infiltration, atrophy, inflammation, and the type and distribution of the lesions. Results. MRI was abnormal in all patients. Fatty infiltration and atrophy were more frequent in patients with sIBM (p < 0.05). Inflammation as the sole abnormality was preferentially encountered in PM (p = 0.05). Widespread abnormalities were more frequent in sIBM (p < 0.01). Abnormalities in PM tended to be distributed along the fascia. Involvement of the anterior group, an asymmetrical distribution, and a distal predominance were all more frequent in sIBM (p < 0.001). Conclusion. Despite some overlap in MRI findings between the 2 diseases, MRI was useful for distinguishing PM from sIBM. (J Rheumatol 2002;29:1897-906) Key Indexing Terms:
MAGNETIC RESONANCE IMAGING
From the Departments of Radiology and Internal Medicine, Neuropathology, Institute of Myology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. Supported by the Association Française Contre les Myopathies. E. Dion, MD, Assistant Professor; P. Cherin, MD, PhD, Professor; C. Payan, MD; J-C. Fournet, MD; T. Papo, MD, Professor; T. Maisonobe, MD; E. Auberton, MD; O. Chosidow, MD, PhD, Professor; P. Godeau, MD, Professor; J-C. Piette, Professor; S. Herson, MD, Professor; P. Grenier, MD, Professor, Head, Department of Radiology. Address reprint requests to Dr. E. Dion, Radiologie, Hôpital Pitié-Salpêtrière, 83 Boulevard de l'hôpital, 75651 Paris cedex 13, France. E-mail: elisabeth.dion@psl.ap-hop-paris.fr Submitted July 16, 2001; revision accepted March 20, 2002.
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