 |
|
|
 |
Interleukin 8 Gene Polymorphism Is Associated with Increased Risk of Nephritis in Cutaneous Vasculitis MAHSA M. AMOLI, WENDY THOMSON, ALI H. HAJEER, MARIA C. CALVIÑO, CARLOS GARCIA-PORRUA, WILLIAM E.R. OLLIER, and MIGUEL A. GONZALEZ-GAY
ABSTRACT.
Methods. Fifty patients (25 men) from Northwest Spain with primary cutaneous vasculitis classified as HSP according to proposed criteria were studied. All patients were required to have had at least 2 years' followup. Patients and ethnically matched controls were genotyped for IL-8, ENA-78, and RANTES gene polymorphisms. Results. No allele or genotype differences between patients fulfilling HSP classification criteria and controls were observed for any of the chemokines. However, a significantly increased frequency of allele A of the IL-8 gene polymorphism was found in patients with HSP who developed renal manifestations compared with patients without renal involvement (p = 0.02; pcorr = 0.036). Moreover, the genotype distribution in HSP patients with and without renal involvement showed statistically significant differences (p = 0.02). Conclusion. In unselected patients with cutaneous vasculitis, carriage of IL-8 allele A influences the susceptibility to renal involvement. (J Rheumatol 2002;29:2367-70) Key Indexing Terms:
HENOCH-SCHÖNLEIN PURPURA From the ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom, and the Divisions of Rheumatology and Pediatrics Hospital Xeral-Calde, Lugo, Spain. M.M. Amoli, MD; W. Thomson. PhD; A.H. Hajeer, PhD; W.E.R. Ollier, PhD, ARC Epidemiology Unit, Manchester University Medical School; M.C. Calviño, MD, Pediatrics Division; C. Garcia-Porrua, MD, PhD; M.A. Gonzalez-Gay, MD, PhD, Rheumatology Division, Hospital Xeral-Calde. Address reprint requests to Dr. M.A. Gonzalez-Gay, Rheumatology Division, Hospital Xeral-Calde, c) Dr. Ochoa s/n, 27004 Lugo, Spain. E-mail: miguelaggay@hotmail.com Submitted January 9, 2002; revision accepted May 18, 2002.
|