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Active Ingredient Consistency of Commercially Available Glucosamine Sulfate Products ANTHONY S. RUSSELL, ALI AGHAZADEH-HABASHI, and FAKHREDDIN JAMALI
ABSTRACT.
Methods. We analyzed in a coded, blind manner 14 commercially available capsules or tablets of GLS, plus one herbal mixture as a control. We used a high performance liquid chromatography system as described. Results. The amount of free base varied from 41 to 108% of the mg content stated on the label; the amount of glucosamine varied from 59 to 138% even when expressed as sulfate. Conclusion. If GLS is used as a therapeutic agent, it is important that the products conform to a standard in their description. The content is probably best expressed in terms of free base. (J Rheumatol 2002;29:2407-9) Key Indexing Terms:
GLUCOSAMINE
From the Faculties of Pharmacy and Medicine, University of Alberta, Edmonton, Alberta, Canada. A.S. Russell, FRCPC, Professor of Medicine; A. Aghazadeh-Habashi, PhD, Post Doctoral Fellow; F. Jamali, PhD, Professor and Associate Dean, Faculty of Pharmacy. Address reprint requests to Dr. A.S. Russell, 526 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2. Submitted November 7, 2001; revision accepted May 21, 2002.
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