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HLA-B35 Association with Nephritis in
Henoch-Schönlein Purpura
MAHSA M. AMOLI, WENDY THOMSON, ALI H. HAJEER, MARIA C. CALVIÑO, CARLOS GARCIA-PORRUA, WILLIAM E.R. OLLIER, and MIGUEL A. GONZALEZ-GAY
ABSTRACT.
Methods. A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. Results. When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. Conclusion. Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP. (J Rheumatol 2002;29:948-9) Key Indexing Terms:
HENOCH-SCHÖNLEIN PURPURA
From the ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom, and the Divisions of Rheumatology and Pediatrics, Hospital Xeral-Calde, Lugo, Spain. M.M. Amoli, MD; W. Thomson, PhD; A.H. Hajeer, PhD; W.E.R. Ollier, PhD, ARC Epidemiology Unit, Manchester University Medical School; M.C. Calviño, MD, Pediatrics Division; C. Garcia-Porrua, MD, PhD; M.A. Gonzàlez-Gay, MD, PhD, Rheumatology Division, Hospital Xeral-Calde. Address reprint requests to Dr. M.A. González-Gay, Rheumatology Division, Hospital Xeral-Calde, c) Dr. Ochoa s/n, 27004 Lugo, Spain. E-mail: miguelaggay@hotmail.com Submitted March 13, 2001; revision accepted November 5, 2001. |