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The Frequency of Thrombotic Thrombocytopenic Purpura in Patients with Systemic Lupus Erythematosus Undergoing Kidney Biopsy
AUGUSTINE M. MANADAN, CHARLOTTE HARRIS, MELVIN M. SCHWARTZ, and JOEL A. BLOCK
ABSTRACT. Objective. To characterize the frequency of thrombotic thrombocytopenic purpura (TTP) among patients with systemic lupus erythematosus (SLE) undergoing kidney biopsy. Methods. A retrospective review of all renal biopsies of patients with SLE at Rush-Presbyterian-St. Luke's Medical Center was performed for the years 1989 to 2001. Results. Four cases of clinical and histopathological TTP were identified among the 257 patients with SLE who underwent renal biopsy during the 12 year study period. Conclusion. TTP appears to occur at higher than expected frequency among SLE patients undergoing biopsy for unexplained renal failure. (J Rheumatol 2003;30:1227–30) Key Indexing Terms:
THROMBOTIC THROMBOCYTOPENIC PURPURA
From Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA. A.M. Manadan, MD, Fellow in Rheumatology; C. Harris, MD, Assistant Professor, Section of Rheumatology; M.M. Schwartz, MD, Professor, Department of Pathology; J.A. Block, MD, Professor and Director, Section of Rheumatology. Address reprint requests to Dr. A.M. Manadan, Section of Rheumatology, 1725 West Harrison, Suite 1017, Chicago, IL, 60612. E-mail: amanadan@rush.edu Submitted May 15, 2002; revision accepted October 18, 2002. |