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Case Report
Linear Scleroderma en Coup de Sabre and Brain Calcification: Is There a Pathogenic Relationship?
DIANA ELSA FLORES-ALVARADO, JORGE A. ESQUIVEL-VALERIO, MARIO GARZA-ELIZONDO, and LUIS R. ESPINOZA ABSTRACT. Extracutaneous calcifications are rare in scleroderma and related conditions. We describe a female patient with linear scleroderma en coup de sabre and a longstanding clinical history of tonic and clonic convulsions. Radiographic study showed extensive cerebral calcifications in the right occipital hemisphere, homolateral to the involved side of her face. This report further suggests a relationship between localized scleroderma and neurological manifestations. Brain imaging studies should be routinely performed in scleroderma patients exhibiting neurological manifestations, especially seizure disorder. (J Rheumatol 2003;30:193-5) Key Indexing Terms:
LINEAR SCLERODERMA
From the Departments of Medicine, Sections of Rheumatology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA; and Universidad Autonoma de Nuevo Leon, Leon, Mexico. D.E. Flores-Alvarado, MD, Research Fellow in Rheumatology, Louisiana State University Health Sciences Center (LSU-HSC); J.A. Esquivel-Valerio, MD, Staff Physician; M.A. Garza-Elizondo, MD, Professor, Department of Medicine, Section of Rheumatology, Universidad Autonoma de Nuevo Leon; L.R. Espinoza, MD, Professor and Chief, Section of Rheumatology, LSU-HSC. Address reprint requests to Dr. D.E. Flores-Alvarado, Section of Rheumatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112-2822. Submitted January 22, 2002; revision accepted June 24, 2002. |