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Risk Factors for Incident Self-Reported Arthritis in a 20 Year Followup of the Alameda County Study Cohort
WILLIAM G. SEAVEY, JOHN H. KURATA, and RICHARD D. COHEN
ABSTRACT.
Methods. Altogether, 1149 women and 964 men from the Alameda County Study Cohort without self-reported arthritis in 1974 were assessed for incident self-reported arthritis in 1994. Results. In a multivariate model, the following variables were associated with increased odds of incident arthritis: increasing age (age 45–49, odds ratio 2.00, 95% confidence interval 1.40–2.85; age 50+, OR 3.13, 95% CI 2.32–4.22), BMI for women only (4th quintile, OR 1.65, 95% CI 1.05–2.60; 5th quintile, OR 1.88, 95% CI 1.19–2.95), female sex (OR 1.48, 95% CI 1.20–1.83), and ³ 5 depressive symptoms (OR 1.53, 95% CI 1.12–2.10). Leisure-time physical activity in the highest quartile was protective (OR 0.69, 95% CI 0.51–0.95). All other factors were not associated with arthritis. Conclusion. This study indicates that depressive symptoms, as well as age, sex, and BMI, are independent risk factors for arthritis. This is the first longitudinal population based study to examine and establish that prior depressive symptoms are a risk factor for arthritis. (J Rheumatol 2003;30:2103-11) Key Indexing Terms:
SELF-REPORTED ARTHRITIS
From the California Department of Health Services, Sacramento; Department of General Internal Medicine, University of California at Davis Medical Center, Sacramento; and the Human Population Laboratory, Public Health Institute, Berkeley, California, USA. Supported by the Preventive Health and Health Services Block Grant and "Reducing the Burden of Arthritis and Other Rheumatic Conditions – Program Announcement 99074" from the Centers for Disease Control and Prevention; and grant 1R37AG11375 from the National Institute of Aging. Data were drawn from the Alameda County Study, a project of the California Department of Health Services. W.G. Seavey, MD, MPH, Fellow in Geriatrics and Public Health, University of California at Davis Medical Center; J.H. Kurata, PhD, MPH, Chief, Chronic Disease Epidemiology Section, California Department of Health Services; R.D. Cohen, MA, Senior Research Scientist, Human Population Laboratory. Address reprint requests to Dr. J. Kurata, Chronic Disease Epidemiology and Control Section, California Department of Health Services, 1616 Capitol Avenue, MS 7212, PO Box 942732, Sacramento, CA 94234-7320. E-mail: jkurata@dhs.ca.gov Submitted February 15, 2002; revision accepted March 20, 2003. |