A 2-Phase Screening Process for Patients with Wegener's Granulomatosis: A Pilot Study

GRACIELA S. ALARCÓN, LARRY W. MORELAND, MICHAEL J. SILLERS, ELLIOTT MORGAN, and WILLIAM R. CARROLL

ABSTRACT.

A 2-phase screening process for patients with persistent upper respiratory tract manifestations for the detection of Wegener's granulomatosis (WG) was tested in 28 patients in this pilot study. One patient with WG was identified. A larger study is warranted. (J Rheumatol 2003;30:2420-1)

Key Indexing Terms:

WEGENER'S GRANULOMATOSIS
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
UPPER RESPIRATORY TRACT

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From the Department of Medicine, Division of Clinical Immunology and Rheumatology; and the Department of Surgery, Division of Otolaryngology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Supported by General Clinical Research Center grant M01-RR00032 and an unrestricted educational grant from HMR (now Aventis).

G.S. Alarcón, MD, MPH, Jane Knight Lowe Chair of Medicine in Rheumatology; L.W. Moreland, MD, Anna Lois Waters Chair of Medicine in Rheumatology, Division of Clinical Immunology and Rheumatology; M.J. Sillers, MD, J.J. Hicks Associate Professor of Surgery; E. Morgan, MD, Associate Professor of Surgery; W.R. Carroll, MD, Associate Professor of Surgery, Division of Otolaryngology.

Address reprint requests to Dr. G.S. Alarcón, Division of Clinical Immunology and Rheumatology, Department of Medicine, 615 MEB, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Submitted November 15, 2002; revision accepted April 14, 2003.

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