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Epidemiology of Systemic Lupus Erythematosus in Northwest Greece 1982-2001
YANNIS ALAMANOS, PARASKEVI V. VOULGARI, CHRISTOS SIOZOS, PELAGIA KATSIMPRI, STYLIANOS TSINTZOS, GEORGIOS DIMOU, EUDOKIA N. POLITI, ANTONIA RAPTI, GIANNA LAINA, and ALEXANDROS A. DROSOS
ABSTRACT.
Methods. Cases were recorded from 3 sources: inpatients and outpatients referred to the rheumatology clinic of the Ioannina University Hospital; inpatients and outpatients referred to the rheumatology clinic of Ioannina General Hospital; and patients referred to private rheumatologists practicing in the study area. All patients identified between January 1, 1982, and December 31, 2001, resident in the study area were included. Diagnosis was confirmed by the 1982 revised criteria of the American College of Rheumatology. Incidence and prevalence rates were calculated as number of cases per hundred thousand inhabitants. Population data were based on the 1981, 1991, and 2001 National Census. Results. A total of 178 cases of SLE were diagnosed during the study period, giving a mean annual incidence rate of 1.9 cases/100,000 inhabitants (95% CI 1.49-2.31). The female/male ratio was 7.4. A significant variation of SLE rates among different districts of the study area was observed. Incidence rates were higher for the urban population. The peak of incidence was observed in the 30-49 age group for both sexes. There was a slight increase in the incidence of SLE during the study period. The 5 year survival rate was 96.8% and the 10 year survival rate was 90.3%. Conclusion. We found a relatively low frequency of SLE in northwest Greece. Age at diagnosis was younger than expected. (J Rheumatol 2003;30:731-5) Key Indexing Terms:
SYSTEMIC LUPUS ERYTHEMATOSUS
From the Department of Hygiene and Epidemiology and the Department of Internal Medicine, Medical School, University of Ioannina; and General Hospital of Ioannina, Ioannina, Greece. Y. Alamanos, MD, Assistant Professor; S. Tsintzos, Medical Student, Department of Hygiene and Epidemiology; P.V. Voulgari, MD, Attending Rheumatologist; P. Katsimpri, MB, BS, Fellow in Rheumatology; A.A. Drosos, MD, FACR, Professor of Medicine/Rheumatology, Department of Internal Medicine; C. Siozos, MD, Consultant Rheumatologist, General Hospital of Ioannina; G. Dimou, MD, Private Practice Rheumatologist; E.N. Politi, MD, Private Practice Rheumatologist; A. Rapti, MD, Private Practice Rheumatologist; G. Laina, MD, Private Practice Rheumatologist. Address reprint requests to Dr. A.A. Drosos, Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece. E-mail: adrosos@cc.uoi.gr Submitted May 8, 2002; revision accepted September 23, 2002.
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