Abstract: Pregnancy Outcome in Patients with Adult Onset Still's Disease

Pregnancy Outcome in Patients with Adult Onset Still's Disease

MO YIN MOK, YI LO, PIK YIU LEUNG, and CHAK SING LAU

ABSTRACT.

Pregnancy outcome of patients with adult onset Still's disease (AOSD) has not been addressed. We report the maternal and fetal morbidity of 5 pregnancies from 3 Chinese patients with AOSD and review another 17 pregnancies from 14 patients reported in the English literature. Nine patients had their first manifestation in the 5th to 6th gestational month. Disease relapse in patients with known AOSD occurred most commonly in the post-partum period. Most did not respond satisfactorily to nonsteroidal antiinflammatory agents alone, but responded to administration of corticosteroids, especially in high doses. (J Rheumatol 2004;31:2307-9)

Key Indexing Terms:

EXACERBATION
FETAL OUTCOME
MATERNAL OUTCOME

From the Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

M.Y. Mok, MBBS (HK), MRCP (UK), Rheumatologist; Y. Lo, Research Assistant; P.Y. Leung, Research Assistant; C.S. Lau, MBChB (Dundee), MD (Dundee), FRCP (UK), Professor of Medicine.

Address reprint requests to Dr. M.Y. Mok, Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong.

Submitted December 11, 203; revision accepted May 26, 2004.