Case Report

Nonmyeloablative Stem Cell Transplant in a Patient with Advanced Systemic Sclerosis and Systemic Lupus Erythematosus

OLA KHORSHID, CHITRA HOSING, SAMER BIBAWI, NAOTO UENO, JOHN REVEILLE, MAUREEN D. MAYES, and RICHARD E. CHAMPLIN

ABSTRACT.

Systemic sclerosis (SSc) is an uncommon connective tissue disease characterized by excessive collagen deposition within the skin and internal organs. Most patients with diffuse severe SSc are treated with immunosuppressive agents, but patients with advanced disease have very high 5-year mortality rates despite adequate therapy. We describe a patient with both diffuse cutaneous SSc and systemic lupus erythematosus who showed mixed chimerism 29 months after undergoing nonmyeloablative stem cell transplant. She experienced remission of both diseases. (J Rheumatol 2004; 31:2513-6)

Key Indexing Terms:

NONMYELOABLATIVE ALLOGENEIC STEM CELL TRANSPLANT
SYSTEMIC SCLEROSIS

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From the Division of Blood and Marrow Transplantation, The University of Texas M.D. Anderson Cancer Center, Houston; and the Division of Rheumatology and Clinical Genetics, The University of Texas–Houston Health Science Center, Houston, Texas, USA.

O. Khorshid, MD; C. Hosing, MD; S. Bibawi, MD; N. Ueno, MD, PhD; R.E. Champlin, MD, M.D. Anderson Cancer Center; J. Reveille, MD; M.D. Mayes, MD, MPH, University of Texas–Houston Health Science Center.

Address reprint requests to Dr. C. Hosing, Department of Blood and Marrow Transplantation, Unit 423, 1515 Holcombe Boulevard, Houston, TX 77030. E-mail: cmhosing@mdanderson.org

Submitted February 4, 2004; revision accepted June 17, 2004.

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