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N-Acetyl Transferase Genotypes in Relation to Risk of Developing Systemic Lupus Erythematosus
GLINDA S. COOPER, EDWARD L. TREADWELL, MARY ANNE DOOLEY, E. WILLIAM ST. CLAIR, GARY S. GILKESON, and JACK A. TAYLOR
ABSTRACT.
Methods. DNA samples were collected from 243 recently diagnosed cases and 298 controls enrolled in a population based case-control study conducted in 60 counties in North Carolina and South Carolina, USA. Results. There was no association between SLE and NAT1 genotype (OR 0.96, 95% CI 0.65, 1.4 for the presence of a *10 allele) or NAT2 genotype (OR 1.1, 95% CI 0.73, 1.6 for the slow- compared with fast-acetylation genotype). We saw some evidence of interaction between NAT genotypes and use of hair dyes (a source of arylamines), with higher risk seen among hair dye users who had both the *10 NAT1 allele and the NAT2 slow-acetylation genotype (OR 2.9, 95% CI 1.2, 6.9 in this subgroup compared with all others). Conclusion. Our results suggest that although there is little overall association between NAT genotypes and risk of developing SLE, the interaction between NAT1 and NAT2 and specific exposures such as hair dyes may be important. This finding highlights the need to consider exposure when assessing genetic susceptibility. (J Rheumatol 2004;31:76-80) Key Indexing Terms:
SYSTEMIC LUPUS ERYTHEMATOSUS
From the Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina; Division of Rheumatology, University of North Carolina, Chapel Hill, North Carolina; the Division of Rheumatology, East Carolina University School of Medicine, Greenville, North Carolina; Division of Rheumatology, Duke University Medical Center, Durham, North Carolina; and the Medical Research Service, Ralph H. Johnson Veterans Administration Medical Center and the Medical University of South Carolina, Charleston, South Carolina. Supported by the Division of Intramural Research of the National Institute of Environmental Health Sciences and the National Center for Minority Health and Health Disparities of the National Institutes of Health. G.S. Cooper, PhD, Investigator, National Institute of Environmental Health Sciences; M.A. Dooley, MD, Associate Professor, University of North Carolina at Chapel Hill; E.L. Treadwell, MD, Professor, East Carolina University School of Medicine; E.W. St. Clair, MD, Professor of Medicine, Duke University Medical Center; G.S. Gilkeson, MD, Professor, Ralph H. Johnson Veterans Administration Medical Center and the Medical University of South Carolina; J.A. Taylor, MD, PhD, Investigator, National Institute of Environmental Health Sciences. Address reprint requests to Dr. G.S. Cooper, Epidemiology Branch A3-05, NIEHS, PO Box 12233, Durham, NC 27709. E-mail: cooper1@niehs.nih.gov. Submitted October 22, 2002; revision accepted July 4, 2003. |