Case Report

Destructive Arthritis in a Patient with Haim-Munk Syndrome

MERAV LIDAR, ABRAHAM ZLOTOGORSKI, PNINA LANGEVITZ, NURIT TWEEZER-ZAKS, and GISELE ZANDMAN-GODDARD

ABSTRACT.

Haim-Munk and Papillon-Lefèvre are 2 closely related syndromes, inherited in an autosomal recessive pattern, manifested by palmoplantar keratoderma and early, destructive periodontitis. Recently, mutations in the cathepsin C gene have been recognized in both syndromes. We describe a patient with Haim-Munk syndrome (palmar plantar keratosis and periodontitis) and destructive arthritis of the wrists and shoulder joints, an association that has not been previously described. (J Rheumatol 2004;31:814-7)

Key Indexing Terms:

HAIM-MUNK SYNDROME
CATHEPSIN C
PALMOPLANTAR KERATODERMA
DESTRUCTIVE PERIODONTITIS

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From the Departments of Medicine B and F and the Rheumatology Unit, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer; and the Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

M. Lidar, MD; P. Langevitz, MD; N. Tweezer-Zaks, MD, Department of Medicine F and Rheumatology Unit, Sheba Medical Center; A. Zlotogorski, MD, Department of Dermatology, Hadassah-Hebrew University Medical Center; G. Zandman-Goddard, MD, Rheumatology Unit and Department of Medicine B, Sheba Medical Center.

Address reprint requests to Dr. G. Zandman-Goddard, Department of Medicine B, Sheba Medical Center, Tel-Hashomer 52621, Israel. E-mail: gzgodd01@sheba.health.gov.il

Submitted April 15, 2003; revision accepted November 11, 2003.

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