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Case Report
Efficacy of Rituximab in Refractory Polymyositis
OLIVIER LAMBOTTE, RAMI KOTB, GWENOLA MAIGNE, FRANÇOIS-XAVIER BLANC, CÉCILE GOUJARD, and JEAN FRANÇOIS DELFRAISSY ABSTRACT. We describe the effectiveness of rituximab, an anti-B lymphocyte monoclonal antibody, in a case of refractory polymyositis with interstitial pulmonary disease and anti-Jo-1 autoantibody (antisynthetase syndrome). Rituximab was well tolerated, and its efficacy in inflammatory myositis should be evaluated. (J Rheumatol 2005;32:1369-70) Key Indexing Terms:
POLYMYOSITIS From the Department of Internal Medicine, Bicêtre Hospital, Le Kremlin Bicêtre, Paris, France. O. Lambotte, MD, PhD; R. Kotb, MD; G. Maigne, MD; F-X. Blanc, MD, PhD; C. Goujard, MD; J.F. Delfraissy, MD. Address reprint requests to Dr. O. Lambotte, Department of Internal Medicine, CHU du Kremlin Bicêtre, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre, Paris, France. E-mail: olivier.lambotte@bct.ap-hop-paris.fr Accepted for publication March 23, 2005. |