Abstract: Transplant of Mesenchymal Stem Cells and Hydroxyapatite Ceramics to Treat Severe Osteochondral Damage After Septic Arthritis of the Knee

Transplant of Mesenchymal Stem Cells and Hydroxyapatite Ceramics to Treat Severe Osteochondral Damage After Septic Arthritis of the Knee

NOBUO ADACHI, MITSUO OCHI, MASATAKA DEIE, and YOHEI ITO

ABSTRACT.

We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA). We confirmed successful cartilage-like tissue regeneration by a second arthroscopy. Biopsy of the repaired tissue revealed cartilage-like regeneration and bone formation. We were able to regenerate new bone and cartilage-like tissue in a one-stage operation, without sacrificing autologous bone or other tissue. This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis. (J Rheumatol 2005;32:1615-8)

Key Indexing Terms:

MESENCHYMAL STEM CELL
HYDROXYAPATITE CERAMICS
OSTEOCHONDRAL DEFECT
SEPTIC ARTHRITIS
TISSUE ENGINEERING

From the Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

N. Adachi, MD, PhD, Assistant Professor; M. Ochi, MD, PhD, Professor and Chairman, Department of Orthopaedic Surgery; M. Deie, MD, PhD, Assistant Professor; Y. Ito, MD, Postgraduate Student.

Address reprint requests to Dr. N. Adachi, Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. E-mail: nadachi@hiroshima-u.ac.jp

Accepted for publication April 20, 2005.