Abstract: Myocarditis and Sacroiliitis: 2 Previously Unrecognized Manifestations of Tumor Necrosis Factor Receptor Associated Periodic Syndrome

Myocarditis and Sacroiliitis: 2 Previously Unrecognized Manifestations of Tumor Necrosis Factor Receptor Associated Periodic Syndrome

STEPHANIE TROST and CARLOS D. ROSÉ

ABSTRACT.

Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is an autosomic-dominant periodic syndrome associated with mutations in the extracellular domain of the 55 kDa TNF receptor. Clinically, episodes of severe myalgia, arthralgia/arthritis, sterile peritonitis, scrotal inflammation, serositis, migratory rash, conjunctivitis, and recurrent fever are characteristic. We describe a 9-year-old African American boy with the P46L mutation of the TNF receptor who presented with 2 previously unrecognized manifestations: sacroiliitis and myocardiopathy, both showing a reversible course. (J Rheumatol 2005;32:175-7)

Key Indexing Terms:

MYOCARDITIS
SACROILIITIS
PEDIATRIC
TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PERIODIC SYNDROME

From the Department of Rheumatology, Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.

C.D. Rosé, MD, CIP, Professor of Pediatrics; S. Trost, MD.

Address reprint requests to Dr. C.D. Rosé, Department of Rheumatology, Alfred I. duPont Hospital for Children, 1600 Rockland Road, PO Box 269, Wilmington, DE 19899. E-mail: www.nemours.org

Submitted January 12, 2004; revision accepted August 16, 2004.