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Non-Inflammatory Joint Pain in Patients with Inflammatory Bowel Disease Is Prevalent and Has a Significant Impact on Health Related Quality of Life
ØYVIND PALM, TOMM BERNKLEV, BJØRN MOUM, and JAN TORE GRAN
ABSTRACT. Methods. In a population based cohort, 521 patients (80%) were clinically investigated 6 years after onset of IBD. NIJP was defined as a history of joint pain during the last 3 months prior to examination and the absence of concomitant signs or symptoms of inflammatory or degenerative joint disease or chronic pain syndromes. HRQOL was registered by the generic Medical Outcome Study Short Form 36 (SF-36) and by the disease specific IBDQ. Results. NIJP was reported by 85 (16%) patients and significantly more often in conjunction with Crohn's disease (CD, 22%) compared to ulcerative colitis (UC, 14%). The prevalence of NIJP was similar in men and women. No correlation with extension of intestinal disease, use of systemic medication, or frequency of surgery was found. NIJP exerted significant impact on HRQOL measured by SF-36 and IBDQ. Conclusions. NIJP occurs frequently in IBD and more often in CD than in UC. NIJP significantly alters HRQOL and should be taken into account in trials estimating outcome in IBD and in clinical practice by attending clinicians. (J Rheumatol 2005;32:1755-9) Key Indexing Terms:
ARTHRALGIA
From the Department of Rheumatology, Østfold Hospital, Sarpsborg; and the Institute of Clinical Medicine and Departments of Medicine and Rheumatology, Rikshospitalet University Hospital, Oslo, Norway. Supported by The Research Council of Norway, The Norwegian Women's Public Health Association, The Norwegian Rheumatism Association, The Norwegian Rheumatological Association, Lions Clubs International Norway, Astra Norway AS, Nycomed Pharma AS, and the Østfold Hospital Research Foundation. Ø. Palm, MD, PhD, Department of Rheumatology, Østfold Hospital; T. Bernklev, Cand Pharm, Institute of Clinical Medicine ; B. Moum, MD, PhD, Department of Medicine; J.T. Gran, MD, PhD, Professor, Department of Rheumatology, Rikshospitalet University Hospital. Address reprint requests to Dr. Ø. Palm, Sarpsborg, Roald Amundsens gate 17, N-1723 Sarpsborg, Norway. E-mail: Oyvind.Palm@so-hf.no Accepted for publication April 11, 2005. |