Case Report

Rosai-Dorfman Disease in a Patient with Systemic Lupus Erythematosus

PRIMAL P. KAUR, RUTH C. BIRBE, and RAPHAEL J. DeHORATIUS

ABSTRACT.

Rosai-Dorfman disease (RDD), also known as sinus histocytosis with massive lymphadenopathy, is a clinically benign, frequently chronic, painless lymphadenopathy. It can also involve extranodal sites. We describe a 37-year-old man with a recent diagnosis of systemic lupus erythematosus and antiphospholipid antibody syndrome who had lacrimal gland and orbital involvement and nodal and extranodal sites with RDD. (J Rheumatol 2005;32:951-3)

Key Indexing Terms:

ROSAI-DORFMAN DISEASE
SYSTEMIC LUPUS ERYTHEMATOSUS
SINUS HISTIOCYTOSIS
MASSIVE LYMPHADENOPATHY

---

From the Division of Rheumatology, Department of Medicine; and Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

P.P. Kaur, MD Senior Clinical Fellow, Division of Rheumatology, Department of Medicine (currently Assistant Professor of Medicine, Temple University School of Medicine, Philadelphia, PA); R.J. DeHoratius, MD, Fellowship Program Director, Division of Rheumatology, Professor of Medicine; R.C. Birbe, MD, Pathology Resident PGY IV, Department of Pathology, Anatomy and Cell Biology (currently Surgical Pathology Fellow, Fox Chase Cancer Center, Philadelphia, PA).

Address reprint requests to Dr. R.J. DeHoratius, Division of Rheumatology, Thomas Jefferson University, 613 Curtis Bldg., 1015 Walnut Street, Philadelphia, PA 19107.

Submitted May 25, 2004; revision accepted November 22, 2004.

---