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ANDREW J. HEAD, LINDA K. MYERS, MITCHELL A. WATSKY, MARK W. GREENWELL, KAREN D. BARROW, JEAN A. MICHELSON, and LAURA D. CARBONE ABSTRACT. Objective. To determine bone mineral content (BMC), bone mineral density (BMD), Z scores, and markers of bone turnover in African American children with juvenile rheumatoid arthritis (JRA). Methods. Eight children with JRA with no prior exposure to corticosteroids were evaluated. Lumbar spine (L1–L4) and total body and total hip BMC and BMD were determined using dual x-ray absorptiometry (DXA), and Z scores (BMD) were calculated. Serum samples of markers of bone turnover including pyridinoline (PYR), N-terminal propeptide of type I procollagen (P1NP), osteocalcin (OC), and bone-specific alkaline phosphatase (BSAP) were measured. Results. The mean Z score (BMD) at the lumbar spine (L1–L4) in patients with JRA was –1.2 ± 0.8. Z scores for total body and total hip were within 1 standard deviation of normal compared with healthy historical controls matched for age, sex, and race. Conclusion. BMD was normal for chronological age (defined as Z score ≥ 2.0) in African American children with JRA who had not previously been treated with corticosteroids. Further studies are needed on the effects of JRA on skeletal health in African American children. (J Rheumatol 2006;33:1001–3) Key Indexing Terms: JUVENILE RHEUMATOID ARTHRITIS
From the Department of Medicine, Division of Rheumatology; Department of Pediatrics; Children's Foundation Research Center at LeBonheur Children's Medical Center; Department of Physiology-Biophysics; Department of Medicine, Division of Nephrology; and General Clinical Research Center, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA. Supported by a grant from the LeBonheur Foundation and supported in part by the National Institutes of Health, National Center for Research Resources, General Clinical Research Center Grant M01 RR00211. A.J. Head, MD; K.D. Barrow, MS; L.D. Carbone, MD, MS, Department of Medicine, Division of Rheumatology; L.K. Myers, MD, Department of Pediatrics and Children's Foundation Research Center; M.A. Watsky, PhD, Department of Physiology-Biophysics; M.W. Greenwell, MD, Division of Nephrology; J.A. Michelson, MA, RD, General Clinical Research Center. Address reprint requests to Dr. L. Carbone, University of Tennessee Health Science Center, Room G326, Coleman Building, 956 Court Avenue, Memphis, TN 38163. E-mail: lcarbone@utmem.edu Accepted for publication December 29, 2005.
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