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SUMO4 and MAP3K7IP2 Single Nucleotide Polymorphisms and Susceptibility to Rheumatoid Arthritis
JAVIER COSTAS, EVA PEREZ-PAMPIN, ISABEL FERREIROS-VIDAL, MARIA TORRES, CHRISTOPHER PHILLIPS, JOSE LUIS VICARIO, JOSE LUIS PABLOS, ANGEL CARRACEDO, JUAN J. GOMEZ-REINO, and ANTONIO GONZALEZ ABSTRACT. Objective. To explore the role of single nuclear polymorphisms (SNP) in 2 candidate genes, SUMO4 and MAP3K7IP2, in susceptibility to rheumatoid arthritis (RA). Methods. Two cohorts from different Spanish towns totalling 635 patients with RA and 826 controls were studied. Six SNP were genotyped by matrix assisted laser desorption-ionization time-of-flight (MALDI-TOF) with the MassARRAY SNP genotyping system. Results. We found no association with susceptibility to RA for any of the SNP including a previously described functional variant in the SUMO4 gene (163A®G). RA susceptibility was independent of the haplotypes defined by the 6 SNP and there was also no association with clinical features of RA. Conclusion. SUMO4 and MAP3K7IP2 SNP did not significantly influence predisposition to and features of RA, in contrast to previous genetic and functional evidence that suggested their involvement. (J Rheumatol 2006;33:1048–51) Key Indexing Terms:
RHEUMATOID ARTHRITIS
From Research Laboratory 2, Rheumatology Unit, and National Genotyping Center, Hospital Clinico Universitario de Santiago, Santiago de Compostela; and the Rheumatology Unit, "12 of October" Hospital and the Regional Transfusion Center, Madrid, Spain. Supported by the Instituto de Salud Carlos III (Spain) with funds from FEDER (European Union) and grants from Xunta de Galicia, Genoma España (Centro Nacional de Genotipado), and Schering-Plough España SA. J. Costas, PhD; M. Torres, BSc, National Genotyping Center, Hospital Clinico Universitario de Santiago; E. Perez-Pampin, MD; I. Ferreiros-Vidal, BA, MA; A. Gonzalez, MD, PhD, Research Laboratory 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago; C. Phillips, MSc; A. Carracedo, MD, PhD, National Genotyping Center, Hospital Clinico Universitario de Santiago and the Institute of Legal Medicine, University of Santiago de Compostela; J.L. Vicario, MD, Regional Transfusion Center; J.L. Pablos, MD, PhD, Rheumatology Unit, "12 of October" Hospital; J.J. Gomez-Reino, MD, PhD, Research Laboratory 2, Rheumatology Unit, Hospital Clinico Universitario de Santiago and the Department of Medicine, University of Santiago de Compostela. Address reprint requests to Dr. A. Gonzalez, Laboratorio de Investigacion 2, Hospital Clinico Universitario de Santiago, 15706 Santiago de Compostela, Spain. E-mail: antonio.gonzalez.martinez.pedrayo@sergas.es Accepted for publication February 6, 2006.
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