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Case Report
Radiologic Improvement of Juvenile Idiopathic Arthritis-Enthesitis-Related Arthritis Following Anti-Tumor Necrosis Factor-a Blockade with Etanercept
SHIRLEY M.L. TSE, RONALD M. LAXER, PAUL S. BABYN, and ANDREA S. DORIA ABSTRACT. Children with juvenile spondyloarthropathy, classified as enthesitis-related arthritis (ERA) under the International League of Associations for Rheumatology classification of juvenile idiopathic arthritis, usually experience both arthritis and enthesitis. Treatment with anti-tumor necrosis factor-a (TNF-a) agents has resulted in dramatic clinical improvement. Radiologic imaging methods useful in the detection, diagnosis, and grading of arthritis and enthesitis include magnetic resonance imaging and ultrasonography. We describe the serial radiologic improvements of arthritis and enthesitis in a child with ERA in response to treatment with the anti-TNF-a agent etanercept. (J Rheumatol 2006;33:1186–8) Key Indexing Terms:
JUVENILE SPONDYLOARTHROPATHY
From the Departments of Pediatrics, Medicine, and Diagnostic Imaging, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada. S.M.L. Tse, MD, Pediatric Rheumatologist, Division of Rheumatology, Department of Pediatrics; R.M. Laxer, MD, Vice President, Clinical and Academic Affairs, Departments of Pediatrics and Medicine; P.S. Babyn, MD, Radiologist-in-Chief; A.S. Doria, MD, General Radiologist, Department of Diagnostic Imaging. Address reprint requests to Dr. S.M.L. Tse, Division of Rheumatology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada. E-mail: shirley.tse@sickkids.ca Accepted for publication December 22, 2005.
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