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Cyclooxygenase-2 Genotype and Rheumatoid Arthritis
KYU HOON LEE, HEE-SANG KIM, AHMED EL-SOHEMY, MARILYN C. CORNELIS, WAN-SIK UHM, and SANG-CHEOL BAE ABSTRACT. Objective. To determine the association between cyclooxygenase-2 (COX-2) genotypes and risk and severity of rheumatoid arthritis (RA) in a Korean population. Methods. A total of 258 Korean patients with RA and 400 control subjects were recruited from Hanyang University Hospital. Subjects were genotyped for the –765G/C polymorphism of the COX-2 gene by RFLP-PCR analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate risk. Severity of RA was assessed by anatomical stage according to Steinbrocker, et al. Results. No association was observed between COX-2 genotype and risk or severity of RA. However, among those without the shared epitope (SE), carriers of the low activity C allele had a lower risk of RA and less severe form of RA than subjects with the G/G genotype. The OR (95% CI) was 0.36 (0.14–0.95) for risk of RA and 0.04 (0.01–0.41) for severity. Conclusion. These results suggest that COX-2 genotyping might be useful in predicting the risk and severity of RA in individuals without the SE. (J Rheumatol 2006;33:1231–4) Key Indexing Terms:
POLYMORPHISM
From the Department of Physical Medicine and Rehabilitation, Division of Rheumatology, and the Hospital for Rheumatic Diseases, Hanyang University, Seoul; Department of Physical Medicine and Rehabilitation, Kyung Hee University, Seoul; Department of Nutritional Sciences, University of Toronto, Toronto, Canada; and Department of Internal Medicine, Division of Rheumatology, and the Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea. Supported in part by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (no. 01-PJ3-PG6-01GN11-0002). K.H. Lee, MD, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, and Hospital for Rheumatic Diseases, Hanyang University; H-S. Kim, MD, PhD, Department of Physical Medicine and Rehabilitation, Kyung Hee University; A. El-Sohemy, PhD; M.C. Cornelis, BSc, Department of Nutritional Sciences, University of Toronto; W-S. Uhm, MD, PhD; S-C. Bae, MD, PhD, MPH, Department of Internal Medicine, Division of Rheumatology, and Hospital for Rheumatic Diseases, Hanyang University. Address reprint requests to Prof. S-C. Bae, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul 133-792, Korea. E mail: scbae@hanyang.ac.kr Accepted for publication February 8, 2006.
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