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The Role of Anti-Cyclic Citrullinated Peptide Antibodies in Predicting Progression of Palindromic Rheumatism to Rheumatoid Arthritis
ANTHONY S. RUSSELL, AL DEVANI, and WALTER P. MAKSYMOWYCH ABSTRACT. Objective. To determine whether the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies at presentation is of prognostic value in patients with palindromic arthritis. Methods. Stored sera, taken around the time of presentation from patients with palindromic arthritis, where available, were assessed for anti-CCP antibodies, and results were correlated with subsequent clinical outcome. Results. Twenty-nine of 61 patients had progressed to rheumatoid arthritis after a mean followup of 5.4 years; 83% of these had had anti-CCP antibodies in their baseline sera. Conclusion. The sensitivity/specificity and likelihood ratios for CCP antibodies were better than rheumatoid factor in predicting outcome. (First Release May 15 2006; J Rheumatol 2006;33:1240–2) Key Indexing Terms:
PALINDROMIC RHEUMATISM
From the Department of Medicine, Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada. A.S. Russell, FRCPC, Professor of Medicine; A. Devani, BA; W. Maksymowych, FRCPC, Professor of Medicine. Address reprint requests to Dr. A. Russell, 562 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2. E-mail: asr@ualberta.ca Accepted for publication February 2, 2006.
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