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Case Report

Anakinra Prevents Symptoms of Familial Cold Autoinflammatory Syndrome and Raynaud's Disease

SAMY K. METYAS and HAL M. HOFFMAN

ABSTRACT.

Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases. (First Release Sept 15 2006; J Rheumatol 2006;33:2085-7)

Key Indexing Terms:

FAMILIAL COLD URTICARIA
FAMILIAL COLD AUTOINFLAMMATORY SYNDROME

RAYNAUD'S DISEASE
ANAKINRA
INTERLEUKIN 1 RECEPTOR ANTAGONIST


From the Division of Rheumatology, University of Southern California, Los Angeles, and the Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, La Jolla, California, USA.

S.K. Metyas, MD, Division of Rheumatology, University of Southern California; H.M. Hoffman, MD, Division of Rheumatology, Allergy, and Immunology, University of California at San Diego.

Address reprint requests to Dr. S.K. Metyas, Division of Rheumatology, University of Southern California, Los Angeles, CA 90033, USA. E-mail: metyas@usc.edu

Accepted for publication May 8, 2006.




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