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Declining Trend in the Incidence of Rheumatoid Factor-Positive Rheumatoid Arthritis in Finland 1980-2000



Objective. To investigate trends in the incidence of rheumatoid arthritis (RA) in Finland.

Methods. We studied all the subjects entitled to receive drug reimbursement for chronic inflammatory joint diseases in 5/21 central hospital districts (population base about 1 million adults) in Finland during 2000. The incidence rates and the mean age at disease onset were compared with those from 1980, 1985, 1990, and 1995.

Results. A total of 714 subjects were entitled to drug reimbursement for chronic inflammatory joint disease that had started at the age of 16 or over. Of them, 321 satisfied the American College of Rheumatology classification criteria for RA, 198 had spondyloarthropathy, and 195 had undifferentiated oligo- or polyarthritis. The incidence of RA was 29.1/100,000 (95% CI 26.0–32.5); the figures for rheumatoid factor (RF)-positive RA and RF-negative RA were 18.2 (95% CI 15.8–21.0) and 10.8 (95% CI 9.0–12.9)/100,000, respectively. The incidence of RA was 36.9 (95% CI 32.1–42.2)/100,000 among women and 20.8 (95% CI 17.2–25.1)/100,000 among men. The age- and sex-adjusted incidence rate ratio declined from 1.00 in the referent year 1980 to 0.55 (95% CI 0.46–0.66) in 2000. A declining trend was evident for the incidence of RF-positive RA (p < 0.001).

Conclusion. We verified the declining trend for the incidence of RF-positive RA in both sexes in Finland. Although the etiology of RA remains unknown, public health measures may reduce the risk of RA in the general population. (First Release Oct 1 2006; J Rheumatol 2006;33:2132-8)

Key Indexing Terms:


From the Department of Medicine, Kuopio University Hospital, Kuopio, and MedCare Foundation, Äänekoski, Finland.

Supported by a grant from the Finnish Cultural Foundation.

O. Kaipiainen-Seppänen, MD, PhD, Department of Medicine, Kuopio University Hospital; H. Kautiainen, BA, MedCare Foundation.

Address reprint requests to Dr. O. Kaipiainen-Seppänen, Department of Medicine, Kuopio University Hospital, P.O. Box 1777, 70211 Kuopio, Finland. E-mail: oili.kaipiainen-seppanen@

Accepted for publication June 2, 2006.

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© 2006. The Journal of Rheumatology Publishing Company Limited.
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