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Prevalence of Symptomatic Knee, Hand, and Hip Osteoarthritis in Greece. The ESORDIG Study
ALEXANDROS A. ANDRIANAKOS, LEONIDAS K. KONTELIS, DIMITRIOS G. KARAMITSOS, SPYROS I. ASLANIDIS, ATHANASIOS I. GEORGOUNTZOS, GEORGE O. KAZIOLAS, KYRIAKI V. PANTELIDOU, ELIZABETH V. VAFIADOU, PETROS C. DANTIS, for the ESORDIG Study Group ABSTRACT. Objective. To assess the prevalence of symptomatic knee, hand, and hip osteoarthritis (OA) in the general adult population of Greece. Methods. This cross-sectional population based study was conducted on the total adult population of 7 communities (8547 subjects) and on 2100 out of 5686 randomly selected subjects in an additional 2 communities. Sixteen rheumatologists visited the target population at their homes; an interview based on a standardized questionnaire was conducted and clinical evaluation and laboratory investigations were done, when necessary. ACR classification criteria were used for diagnosing symptomatic OA. Results. Of the final target population of 10,647 subjects, 8740 (82.1%) participated in the study. The age and sex adjusted prevalence of symptomatic knee, hand, and hip OA was 6.0% (95% CI 5.6–6.4), 2% (1.8–2.2), and 0.9% (0.7–1.1), respectively. Symptomatic knee, hand, and hip OA prevalence was significantly higher among women than men and increased significantly with age. Symptomatic knee OA was significantly more common in the rural compared to urban and suburban populations. Logistic regression analysis showed a significant association of female sex and age ≥ 50 years with all sites of OA, of obesity with knee and hip OA, and of a low level of education with knee OA. Conclusion. Symptomatic knee, hand, and hip OA is common in the general adult population of Greece, showing a female preponderance and a prevalence increasing with age. Female sex and age are risk factors for all sites of OA, obesity for knee and hip OA, and a low level of education for knee OA. (J Rheumatol 2006;33:2507–14) Key Indexing Terms:
PREVALENCE From the Rheumatic Disease Epidemiology Section, Hellenic Foundation for Rheumatological Research, Athens, Greece. A. Andrianakos, MD, Rheumatic Disease Epidemiology Section, Hellenic Foundation for Rheumatological Research, Athens, and Third Department of Internal Medicine, Athens University Medical School, Sotiria Hospital, Athens; D. Karamitsos, MD, Department of Rheumatology, Evangelismos Hospital, Athens; S. Aslanidis, MD, Department of Internal Medicine, Hippokration General Hospital, Thessaloniki; A. Georgountzos, MD, Department of Rheumatology, 3rd IKA Hospital, Athens; L. Kontelis, MD; K. Pantelidou, MD; E. Vafiadou, MD; P. Dantis, MD, Rheumatic Disease Epidemiology Section, Hellenic Foundation for Rheumatological Research, Athens; G. Kaziolas, MD, IKA Health Center, Helioupolis, Athens. In addition to the authors, the following physicians are members of the ESORDIG Study Group: F. Christoyannis, E. Kaskani, P. Krachtis, Z. Nikolia, E. Tavaniotou, P. Trontzas. Address reprint requests to Dr. A. Andrianakos, Hellenic Foundation for Rheumatological Research, 8 Rodon Street, Kantza Pallini Attikis, 153 51 Athens, Greece. E-mail: eire@otenet.gr Accepted for publication August 22, 2006.
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