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A Metaanalysis YOUNG HO LEE, YOUNG HEE RHO, SEONG JAE CHOI, JONG DAE JI, and GWAN GYU SONG
ABSTRACT. Methods. We surveyed studies of ACE I/D polymorphism and SLE using Medline and manual searches. We conducted a metaanalysis of the DD genotype (recessive effect), DD and DI genotype (dominant effect), and D allele of the ACE overall and in each ethnic population. We performed a metaanalysis of ACE I/D polymorphism in SLE and LN. Results. Thirteen comparison studies were included in our metaanalysis consisting of 1411 patients with SLE and 1551 controls. We found no association of ACE I/D polymorphism with SLE in the total sample and by ethnic groups. There was a trend for association of the DD genotype (OR 1.212, 95% CI 0.966–1.520, p = 0.097) and the D allele with SLE in Caucasian patients (OR 1.157, 95% CI 0.991–1.349, p = 0.064); however, this was not statistically significant. The metaanalysis also showed no association of the ACE I/D polymorphisms with LN. Conclusion. This metaanalysis of 2962 subjects showed there is a lack of association of the ACE I/D polymorphism with SLE and LN. (J Rheumatol 2006;33:698-702) Key Indexing Terms:
SYSTEMIC LUPUS ERYTHEMATOSUS
From the Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University, Seoul, Korea. Y.H. Lee, MD, PhD, Assistant Professor of Rheumatology; Y.H. Rho, MD, Clinical Instructor of Rheumatology; S.J. Choi, MD, Clinical Instructor of Rheumatology; J.D. Ji, MD, PhD, Associate Professor of Rheumatology; G.G. Song, MD, PhD, Professor of Rheumatology. Address reprint requests to Dr. Y.H. Lee, Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, 136-705, Korea. E-mail: lyhcgh@korea.ac.kr Accepted for publication October 26, 2005. [MEDLINE] |
