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Increased Expression of N-Methyl-D-Aspartate Receptor Subunit 2D in the Skin of Patients with Fibromyalgia
SEONG-HO KIM, TAE JUNG JANG, and IL SOO MOON ABSTRACT. Objective. We studied the expression of N-methyl-D-aspartate receptors (NMDAR) in skin of patients with fibromyalgia (FM) to investigate their role. Methods. The presence of NMDAR subtype 2B (NR2B) and subtype 2D (NR2D) was examined in skin tissues by immunohistochemistry and immunoblot. Skin tissues from 11 female patients with FM were examined and compared to those of 8 age- and sex-matched healthy controls. Results. NR2D expression was increased in the skin of patients with FM versus controls. There was no difference in the expression of NR2B between FM patients and controls. Conclusion. The increased expression of NMDAR found in FM skin could be indicative of a more generalized increase in other peripheral nerves. This suggests that NR2D-selective antagonists may have implications in the treatment of allodynia in patients with FM. (J Rheumatol 2006;33:785–8)
Key Indexing Terms: FIBROMYALGIA
From the Departments of Internal Medicine, Pathology, and Anatomy, Dongguk University College of Medicine, Gyeongju, Republic of Korea. S-H. Kim, MD, PhD, Department of Internal Medicine; T.J. Jang, MD, PhD, Department of Pathology; I.S. Moon, PhD, Department of Anatomy. Address reprint requests to Dr. S-H. Kim, Dongguk University College of Medicine, 1090-1, Sukjang-Dong, Gyeongju, Gyeongbuk 780-714, Republic of Korea. E-mail: junjan@dongguk.ac.kr Accepted for publication November 28, 2005.
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