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Consensus on a Core Set of Domains for Psoriatic Arthritis

DAFNA D. GLADMAN, PHILIP J. MEASE, VIBEKE STRAND, PAUL HEALY, PHILIP S. HELLIWELL, OLIVER FITZGERALD, ALICE B. GOTTLIEB, GERALD G. KRUEGER, PETER NASH, CHRISTOPHER T. RITCHLIN, WILLIAM TAYLOR, ADE ADEBAJO, JURGEN BRAUN, ALBERTO CAULI, SUELI CARNEIRO, ERNST CHOY, BEN DIJKMANS, LUIZ ESPINOZA, DESIREE van der HEIJDE, ELAINE HUSNI, ENNIO LUBRANO, DENNIS McGONAGLE, ABRAR QURESHI, ENRIQUE R. SORIANO, and JANE ZOCHLING

ABSTRACT.

A psoriatic arthritis (PsA) module was convened at OMERACT 8 in order to achieve consensus on the core domains that should be included in randomized controlled trials and longitudinal observational cohorts of subjects with PsA. Following a plenary session at which current status of measures used to assess PsA were reviewed, and discussion at breakout groups, the group achieved consensus on 6 core domains: peripheral joint activity, skin activity, pain, patient global assessment, physical function, and health-related quality of life. In addition the following domains were considered important but not mandatory: spinal disease, dactylitis, enthesitis, fatigue, nail disease, radiography, physician global assessment, and acute-phase reactants. A research agenda was proposed to include development and validation of instruments for the domains where none existed, and in particular further research was recommended for the following areas: magnetic resonance imaging and ultrasound of joints, enthesitis, skin and synovial tissue analysis, and "participation." (J Rheumatol 2007;34:1167–70)

Key Indexing Terms:

PSORIATIC ARTHRITIS
CLINICAL MEASUREMENTS

CORE SET
DOMAINS
INSTRUMENTS


From The University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada; Swedish Medical Center and University of Washington School of Medicine, Seattle, Washington; Division of Immunology, Stanford University, Portola Valley, California; Division of Dermatology, Tufts University, Boston, Massachusetts; Department of Dermatology, University of Utah, Salt Lake City, Utah; Clinical Immunology Research Center, University of Rochester Medical School, Rochester, New York; Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Academic Unit of Musculoskeletal Medicine, University of Leeds; Leeds Institute of Molecular Medicine, Leeds; Academic Department of Rheumatology, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield; Sir Alfred Baring Garrod Clinical Trials Unit, Academic Department of Rheumatology, King's College London, London, UK; St. Vincent's University Hospital, Dublin, Ireland; Rheumatology Research Unit, Nambour Hospital, Department of Medicine, University of Queensland, Australia; Rehabilitation Teaching and Research Unit, Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Rheumazentrum Ruhrgebiet, Herne, Germany; Rheumatology Unit, Department of Medicine, University of Cagliari, Monserrato; Rheumatology Unit, Fondazione Maugeri, Istituto Scientifico Telese Terme (BN), Italy; Division of Dermatology, University Hospital, Federal University of Rio de Janeiro, Brazil; Department of Rheumatology, VU University Medical Center, Amsterdam; Department of Rheumatology, University Hospital Maastricht, and Caphri Research Institute, University Maastricht, Maastricht, The Netherlands; and Rheumatology Unit, Hospital Italiano de Buenos Aires and Fundacion Pedro M. Catoggio, Buenos Aires, Argentina.

D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Senior Scientist, Toronto Western Research Institute, Director, Psoriatic Arthritis Program, University Health Network; P.J. Mease, MD, Seattle Rheumatology Associates, Chief, Swedish Medical Center Rheumatology Research Division, Clinical Professor, University of Washington School of Medicine; V. Strand, MD, Clinical Associate Professor, Division of Immunology, Stanford University; P. Healy, MBChB, FRACP; P.S. Helliwell, MD, PhD, Rheumatology and Rehabilitation Research Unit, University of Leeds; A.B. Gottlieb, MD, PhD, Professor of Dermatology, Tufts University; O. FitzGerald, MD, FRCP, FRCPI, Newman Clinical Research Professor, Consultant Rheumatologist, Department of Rheumatology, St. Vincent's University Hospital; G.G. Krueger, MD, Department of Dermatology, University of Utah; P. Nash, MBBS, FRACP, Director, Rheumatology Research Unit, Nambour Hospital, Senior Lecturer, Department of Medicine, University of Queensland; C.T. Ritchlin, MD, Associate Professor of Medicine, Director, Clinical Immunology Research Center, University of Rochester Medical School; W.J. Taylor, MBChB, FRACP, FAFRM, Senior Lecturer, Rehabilitation Teaching and Research Unit, Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago; A. Adebajo, MD, Academic Department of Rheumatology, Division of Genomic Medicine, University of Sheffield Medical School; J. Braun, MD, Rheumazentrum Ruhrgebiet; A. Cauli, MD, Rheumatology Unit, Department of Medicine, University of Cagliari; S. Carneiro, MD, Associate Professor of Dermatology, University of the State of Rio de Janeiro (UERJ); E. Choy, MD, Sir Alfred Baring Garrod Clinical Trials Unit, Academic Department of Rheumatology, King's College London; B. Dijkmans, MD, Department of Rheumatology, VU University Medical Center; L.R. Espinoza, MD, Professor, LSU Health Sciences Center; D.M.F.M. van der Heijde, MD, PhD, Professor of Rheumatology, Department of Rheumatology, University Hospital Maastricht, and Caphri Research Institute, University Maastricht; E. Husni, MD, Department of Rheumatic and Immunologic Diseases, Director, Musculoskeletal Outcomes Research, Cleveland; E. Lubrano, MD, PhD, Consultant Rheumatologist, Rheumatology Unit, Fondazione Maugeri, Istituto Scientifico Telese Terme (BN); D. McGonagle, MD, Leeds Institute of Molecular Medicine; A. Qureshi, MD, Department of Dermatology, Brigham and Women's Hospital; E.R. Soriano, MD, Associate Professor of Public Health, Consultant Rheumatologist, Rheumatology Unit, Hospital Italiano de Buenos Aires and Fundacion Pedro M. Catoggio; J. Zochling, MBBS, Mmed (ClinEpi), PhD, Rheumazentrum Ruhrgebiet.

Address reprint requests to Dr. D. Gladman, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, 1E-410B, Toronto, Ontario M5T 2S8, Canada. E-mail: dafna.gladman@utoronto.ca




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