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Association of PTPN22 with Rheumatoid Arthritis Among South Asians in the UK SARABJIT MASTANA, ASHLEY GILMOUR, ANANT GHELANI, HANNAH SMITH, and ASH SAMANTA
ABSTRACT. Methods. DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results. The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95% confidence interval 1.68–20.52). Similar association was observed for genotypes containing *T allele. Conclusion. Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians. (First Release August 1 2007; J Rheumatol 2007;34:1984-6) Key Indexing Terms:
RHEUMATOID ARTHRITIS
From the Human Genetics Laboratory, Department of Human Sciences, Loughborough University, Loughborough; and Department of Rheumatology, UHL, Leicester Royal Infirmary, Leicester, UK. S. Mastana, PhD, Senior Lecturer in Human Genetics; A. Gilmour, MSc, Researcher; A.M. Ghelani, PhD, University Teacher; H. Smith, BSc, Loughborough University; A. Samanta, MD, FRCP, Consultant Rheumatologist, University Hospitals of Leicester. Address reprint requests to Dr. S. Mastana, Human Genetics Laboratory, Department of Human Sciences, Loughborough University, Loughborough LE11 3TU, UK. E-mail: s.s.mastana@lboro.ac.uk Accepted for publication June 6, 2007. |
