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Ligands for Programmed Cell Death 1 Gene in Patients with Systemic Lupus Erythematosus
SHU-CHEN WANG, CHIA-HUI LIN, TSAN-TENG OU, CHENG-CHIN WU, WEN-CHAN TSAI, CHAUR-JONG HU, HONG-WEN LIU, and JENG-HSIEN YEN ABSTRACT. Objective. To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). Methods. One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. Results. The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4–4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3–2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. Conclusion. PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan. (First Release Mar 1 2007; J Rheumatol 2007;34:721-5) Key Indexing Terms:
PROGRAMMED CELL DEATH 1 LIGAND From the Department of Laboratory Medicine and Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital; College of Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung; and the Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan. S-C. Wang, MSc, Department of Laboratory Medicine; C-H. Lin, MSc; T-T. Ou, MD, Attending Physician; C-C. Wu, MD, Attending Physician, Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital; W-C. Tsai, MD, PhD, Associate Professor; H-W. Liu, MD, Professor, Division of Rheumatology, Department of Internal Medicine and College of Medicine, Kaohsiung Medical University; C-J. Hu, MD, Assistant Professor, Department of Neurology, Taipei Medical University Hospital; J-H. Yen, MD, PhD, MSc, Professor, Division of Rheumatology, Department of Internal Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University. Address reprint requests to Dr. J-H. Yen, Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100 Zih-You 1st Road, Kaohsiung City 807, Taiwan. E-mail: jehsye@kmu.edu.tw Accepted for publication December 28, 2006.
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