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A Multicenter Reliability Study of Extremity-Magnetic Resonance Imaging in the Longitudinal Evaluation of Rheumatoid Arthritis
PHILIP G. CONAGHAN, BO EJBJERG, MARISSA LASSERE, PAUL BIRD, CHARLES PETERFY, PAUL EMERY, FIONA McQUEEN, ESPEN HAAVARDSHOLM, PHILIP O'CONNOR, JOHN EDMONDS, HARRY GENANT, and MIKKEL ØSTERGAARD ABSTRACT. There are limited data on the reliability of extremity magnetic resonance imaging (E-MRI) in the longitudinal evaluation of rheumatoid arthritis (RA). Our aim was to assess the interreader reliability of the OMERACT RA MRI score in the assessment of change in disease activity and bone erosion scores using 0.2 T E-MRI hand and wrist images from 2 timepoints, evaluated by 3 readers at different international centers. The intraclass correlation coefficients and smallest detectable difference results for the change scores were generally good for erosions and synovitis, but were not acceptable for bone edema. Overall, E-MRI demonstrated ability to detect change comparable to that reported for high-field MRI for erosion and synovitis. (J Rheumatol 2007;34:857–8) Key Indexing Terms:
EXTREMITY MAGNETIC RESONANCE IMAGING From the Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK; Departments of Rheumatology and Radiology, Copenhagen University Hospitals at Herlev and Hvidovre, Copenhagen, Denmark; Department of Rheumatology, St. George Hospital, University of New South Wales, Sydney, Australia; Synarc Inc., University of California, San Francisco, California, USA; Department of Rheumatology, Auckland University, Auckland, New Zealand; Diakonhjemmet Hospital, University of Oslo, Oslo, Norway; and the Department of Radiology, Chapel Allerton Hospital, Leeds, UK. Dr. Conaghan, Dr. Ejbjerg, and Dr. Østergaard contributed equally to this work. P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Academic Unit of Musculoskeletal Disease, University of Leeds; B. Ejbjerg, MD, PhD, Senior Registrar, Copenhagen University Hospital at Herlev; M. Lassere, MB, BS, Grad Dip Epi, PhD, FRACP, FAFPHM, Associate Professor in Medicine, Department of Rheumatology, St. George Hospital, University of NSW; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Senior Lecturer, University of NSW; C. Peterfy, MD, PhD, Chief Medical Officer, Synarc Inc.; P. Emery, MA, MD, FRCP, ARC Professor in Rheumatology, Academic Unit of Musculoskeletal Disease, University of Leeds; F. McQueen, MD, FRACP, Associate Professor in Rheumatology, Department of Rheumatology, Auckland University; E.A. Haavardsholm, MD, Research Fellow, Diakonhjemmet Hospital, University of Oslo; P. O'Connor, MBBS, MRCP, FRCR, Consultant Skeletal Radiologist, Department of Radiology, Chapel Allerton Hospital; J. Edmonds, MB, BS, MA, FRACP, Director, Professor of Rheumatology, Department of Rheumatology, University of NSW; H. Genant, MD, FACR, FRCR, Professor of Radiology, University of California; M. Østergaard, MD, PhD, DMSc, Professor in Rheumatology/Arthritis, Copenhagen University Hospitals at Herlev and Hvidovre. Address reprint requests to Dr. P.G. Conaghan, Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, United Kingdom. E-mail: p.conaghan@leeds.ac.uk
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