 |
|
|
 |
Computer Based Methods for Measurement of Joint
Space Width: Update of an Ongoing OMERACT Project
JOHN T. SHARP, JANE ANGWIN, MAARTEN BOERS, JEFF DURYEA, GABRIELE von INGERSLEBEN, JAMES R. HALL, JOOST A. KAUFFMAN, ROBERT LANDEWÉ, GEORG LANGS, CÉDRIC LUKAS, JEAN-FRANCIS MAILLEFERT, HEIN J. BERNELOT MOENS, PHILIPP PELOSCHEK, VIBEKE STRAND, and DÉSIRÉE van der HEIJDE ABSTRACT. Computer-based methods of measuring joint space width (JSW) could potentially have advantages over scoring joint space narrowing, with regard to increased standardization, sensitivity, and reproducibility. In an early exercise, 4 different methods showed good agreement on measured change in JSW over time in the small joints of the hands and feet. Despite differences in measurement values between methods, measurement of within-joint change over time showed no systematic differences. The within-method variation was small, with intra-operator variation being smaller than inter-operator variation. Although this initial study was limited in terms of the number of patients and timepoints (total 10), the number of joints was relatively high (340 joints), so the results were considered strong evidence supporting the validity of computer-based JSW measurements to continue the study of the potential value of JSW by comparison of measurements to manual scoring of joint space narrowing using the COBRA trial images. (J Rheumatol 2007;34:874–83) Key Indexing Terms:
JOINT SPACE MEASUREMENT From the University of Washington School of Medicine, Seattle, Washington, USA; GlaxoSmithKline, Middlesex, England; VU University Medical Center, Amsterdam, The Netherlands; Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA; Synarc, San Francisco, California, USA; Snoqualmie, Washington, USA; University of Twente, Enschede, The Netherlands; University Hospital Maastricht, Maastricht, The Netherlands; Graz University of Technology, Graz, Austria; Dijon University Hospital, University of Burgundy, Dijon, France; University Medical Center, Utrecht, The Netherlands; University of Vienna, Vienna, Austria; and Stanford University, Palo Alto, California, USA. J.T. Sharp, MD, Affiliate Professor of Medicine, University of Washington; J. Angwin, MA, Respiratory and Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline R&D, UK; M. Boers, MSc, MD, PhD, Professor of Clinical Epidemiology, VU University Medical Center; J. Duryea, PhD, Assistant Professor, Brigham and Women's Hospital, Harvard University; J.A. Kauffman, Signals and Systems Group, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente; R. Landewé, MD, PhD, Associate Professor of Rheumatology, University Hospital Maastricht; C. Lukas, MD, Rheumatologist, University Hospital Maastricht; J.F. Maillefert, MD, PhD, Associate Professor of Rheumatology, University of Burgundy; H.J. Bernelot Moens, MD, Rheumatologist, Ziekenhuis Groep Twente, Hengelo, The Netherlands; G. Langs, Institute for Computer Graphics and Vision, Graz University of Technology; P. Peloschek, MD, Radiologist, Medical University of Vienna; D.M.F.M. van der Heijde, MD, PhD, Professor of Rheumatology, University Hospital Maastricht; G. von Ingersleben, Radiologist, Synarc; J.R. Hall, Software Engineer, Snoqualmie, WA, USA. Address reprint requests to Dr. J.T. Sharp, 8387 N.E. Sumanee Place, Bainbridge Island, WA 98110, USA. E-mail: johntsharp@comcast.net.
|
