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Case Series
Alendronate-Induced Synovitis
DAVID P. GWYNNE JONES, RUTH L. SAVAGE, and JOHN HIGHTON ABSTRACT. We describe 7 cases of synovitis or arthritis occurring after commencement of alendronate for treatment of osteoporosis. These were cases from our practice or notified to the New Zealand Pharmacovigilance Centre, Dunedin, New Zealand. There was no evidence of rheumatoid arthritis, pyrophosphate arthropathy, or seronegative arthritis in any patient. Symptoms recurred on rechallenge in 5 of the cases. We conclude alendronate should be considered as a possible cause of synovitis or polyarthritis in patients treated with it in the absence of any other pathology. (J Rheumatol First Release Jan 15 2007) Key Indexing Terms:
ALENDRONATE
From the Departments of Medical and Surgical Sciences, Dunedin School of Medicine; and the Centre for Adverse Reactions Monitoring, New Zealand Pharmacovigilance Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand. D.P. Gwynne Jones, FRACS (Orth), Senior Lecturer, Orthopaedic Surgery, Consultant Orthopaedic Surgeon; R.L. Savage, MB BS, MSc (Clin Pharmacol), Senior Research Fellow; J. Highton, MD, FRACP, Professor of Rheumatology. Address reprint requests to D.P. Gwynne Jones, Dunedin Hospital, Orthopaedics, Great King Street, Dunedin, 9024 New Zealand. E-mail: david.gwynne-jones@stonebow.otago.ac.nz Accepted for publication October 2, 2007. |
