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Elevated Serum Insulin-like Growth Factor (IGF-1) and IGF Binding Protein-3 Levels in Patients with Systemic Sclerosis: Possible Role in Development of Fibrosis
YASUHITO HAMAGUCHI, MANABU FUJIMOTO, TAKASHI MATSUSHITA, MINORU HASEGAWA, KAZUHIKO TAKEHARA, and SHINICHI SATO
ABSTRACT. Methods. Serum IGF-1 and IGFBP-3 levels in 92 Japanese patients with SSc were measured by ELISA. Expression of IGF-1 and IGFBP-3 messenger RNA (mRNA) in the skin was quantified by real-time reverse transcription-polymerase chain reaction. Results. Serum IGF-1 and IGFBP-3 levels were significantly elevated in patients with SSc compared with patients with systemic lupus erythematosus or healthy controls. IGF-1 levels were higher in patients with diffuse cutaneous SSc (dcSSc) than in patients with limited cutaneous SSc (lcSSc). Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis. IGF-1 mRNA was upregulated in the affected skin of patients with SSc. There were no significant differences in serum IGFBP-3 levels between dcSSc and lcSSc. IGFBP-3 levels were not associated with skin thickness and pulmonary fibrosis. Patients with increased IGF-1 or IGFBP-3 had lower frequency of telangiectasia than patients with normal levels. Conclusion. These results suggest that both IGF-1 and IGFBP-3 are involved in the development of SSc. The role of IGF-1 appears to be different from that of IGFBP-3. (J Rheumatol First Release Nov 1 2008; doi:10.3899/jrheum.080340) Key Indexing Terms:
SYSTEMIC SCLEROSIS From the Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa; and Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Supported by a grant to Dr. Fujimoto for research on intractable diseases from the Ministry of Health, Labour and Welfare of Japan. Y. Hamaguchi, MD, PhD; M. Fujimoto, MD; T. Matsushita, MD, PhD; M. Hasegawa, MD, PhD; K. Takehara, MD, PhD, Department of Dermatology, Kanazawa University Graduate School of Medical Science; S. Sato, MD, PhD, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences.
Address reprint requests to Dr. M. Fujimoto, Department of Dermatology, Kanazawa University Graduate School of Medical Science, Accepted for publication August 14, 2008.
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