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Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study TUHINA NEOGI, R. CURTIS ELLISON, STEVEN HUNT, ROBERT TERKELTAUB, DAVID T. FELSON, and YUQING ZHANG
ABSTRACT. Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. Results. In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men. (J Rheumatol First Release Nov 15 2008; doi:10.3899/jrheum.080646) Key Indexing Terms:
URIC ACID From the Section of Clinical Epidemiology Research and Training Unit and Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts; University of Utah, Salt Lake City, Utah; and Veterans Affairs Medical Center, University of California at San Diego, San Diego, California, USA. Supported by the American College of Rheumatology-Research and Education Fund (ACR-REF); Arthritis Foundation; National Institutes of Health (NIH) AR 47785; National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement grants U01 HL56563, U01 HL56564, U01 HL56565, U01 HL56566, U01 HL56567, U01 HL56568, and U01 HL56569; NIH HL077360; Veterans Affairs (VA); and TAP Pharmaceuticals. Dr. Neogi is supported by an ACR-REF/Association of Specialty Physicians (ASP) Junior Career Development Award in Geriatric Medicine, Arthritis Foundation Arthritis Investigator Award, and NIH (NIAMS) 1K23AR055127. T. Neogi, MD, FRCPC, Assistant Professor of Medicine, Department of Medicine, Section of Clinical Epidemiology Research and Training Unit; R.C. Ellison, MD, Professor of Medicine, Department of Medicine, Section of Preventive Medicine, Boston University School of Medicine; S. Hunt, PhD, Professor of Medicine, Cardiology Division, University of Utah; R. Terkeltaub, MD, Professor of Medicine, Department of Medicine, Division of Rheumatology, VA Medical Center, University of California at San Diego; D.T. Felson, MD, MPH, Professor of Medicine; Y. Zhang, DSc, Professor of Medicine, Department of Medicine, Section of Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. Address reprint requests to Dr. T. Neogi, Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X-200, Boston, MA 02118. Email: tneogi@bu.edu Accepted for publication September 4, 2008.
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