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Association Between Interleukin 1 Polymorphisms and Rheumatoid Arthritis Susceptibility: A Metaanalysis
YOUNG HO LEE, JONG DAE JI, and GWAN GYU SONG
ABSTRACT. Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. (J Rheumatol First Release Nov 1 2008; doi:10.3899/jrheum.080450) Key Indexing Terms:
INTERLEUKIN 1
From the Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea. Y.H. Lee, MD; J.D. Ji, MD; G.G. Song, MD, Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center. Address reprint requests to Dr. Y.H. Lee, Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea. E-mail: lyhcgh@korea.ac.kr Accepted for publication August 20, 2008.
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