 |
|
|
 |
The Mid-Range of the Adjusted Level of Ferritin Can Predict the Chronic Course in Patients with Adult Onset Still's Disease SANG-WON LEE, YONG-BEOM PARK, JUNG-SOO SONG, and SOO-KON LEE
ABSTRACT. Methods. We retrospectively investigated the medical records of 71 hospitalized patients with AOSD. Patients were divided according to chronic and nonchronic disease course. The initial laboratory results were defined as those at the time of admission, the extremely deviated laboratory results as the highest or the lowest results, and the adjusted laboratory results as area under the curve divided by the days of hospitalization. All measures were compared and the odds ratio (OR) for the chronic disease pattern was assessed. Results. The mean age was 39.7 ± 13.5 years and women accounted for 63 of the total 71 (88.7%). Thirty patients (42.3%) had self-limited disease, 9 (12.7%) intermittent disease, and 23 (32.4%) the chronic disease pattern (32.4%). Nine patients (12.7%) died. The initial levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin, the highest levels of lactate dehydrogenase (LDH) and ferritin, and the adjusted level of ferritin in patients with chronic disease were significantly higher than those with nonchronic disease. Among them, only the middle range of the adjusted ferritin level (784.1~4120.0 ng/ml) was found to have a significant predictive value for the chronic disease pattern (OR 81.7, p = 0.007). Conclusion. A novel measure, the adjusted level of ferritin during the first hospitalization, might be useful to predict progression to chronic disease in patients with AOSD. (J Rheumatol First Release Dec 1 2008; doi:10.3899/jrheum.080537) Key Indexing Terms:
ADULT ONSET STILL'S DISEASE
From the Department of Rheumatology, Chung-Ang University College of Medicine; and Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. S-W. Lee, MD, Department of Rheumatology, Chung-Ang University College of Medicine; Y-B. Park, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine; J-S. Song, MD, PhD, Department of Rheumatology, Chung-Ang University College of Medicine; S-K. Lee, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine. Drs. S-K. Lee and J-S. Song contributed equally to this report. Address reprint requests to Dr. S-K. Lee, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul, South Korea. E-mail: sookonlee@yumc.yonsei.ac.kr; and Dr. J-S. Song, Department of Rheumatology, Chung-Ang University College of Medicine, 224-1 Heuksuk-dong, Dongjak-gu, Seoul, South Korea, 156-755. E-mail: drsong@cau.ac.kr Accepted for publication August 4, 2008.
|
