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Soluble Endothelial Cell Adhesion Molecules and Their Relationship to Disease Activity in Takayasu's Arteritis
NARESH K. TRIPATHY, VINOD CHANDRAN, NAVEEN K. GARG, NAKUL SINHA, and SONIYA NITYANAND
ABSTRACT. Methods. Levels of adhesion molecules were measured by enzyme immunoassay in the sera of 35 patients with TA, 17 healthy controls, and 15 patients with 12 months followup. Results. Compared to controls, patients had elevated levels of sE-selectin (54.5 ± 35.0 vs 36.4 ± 13.0 ng/ml, p < 0.05), sVCAM-1 (280.9 ± 267.6 vs 141.2 ± 76.1 ng/ml, p < 0.05), and sICAM-1 (261.3 ± 168.1 vs 198.3 ± 74.3 ng/ml, p < 0.05). Compared to controls, patients with inactive TA also had elevated levels of sE-selectin (67.4 ± 45.9 vs 36.4 ± 13.0 ng/ml, p < 0.02), sVCAM-1 (327.6 ± 327.8 vs 141.2 ± 76.1 ng/ml, p < 0.02), and sICAM-1 (321.9 ± 179.5 vs 198.3 ± 74.3 ng/ml, p < 0.02). There was no difference between active TA and controls. sE-selectin had a trend towards increased levels in inactive versus active TA (67.4 ± 45.9 vs 44.9 ± 20.3 ng/ml p = 0.059), but there was no difference in sVCAM-1 and sICAM-1 levels between the groups. No adhesion molecule levels showed a change among followup patients. Conclusion. Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease. (First Release June 15 2008; J Rheumatol 2008;35:1842–5) Key Indexing Terms:
TAKAYASU'S ARTERITIS
From the Departments of Hematology, Immunology, and Cardiology; Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India. Supported by an intramural grant of SGPGIMS, Lucknow-226014, India to Dr N.K. Garg. N.K. Tripathy*, PhD, Technical Officer, Department of Hematology; V. Chandran*, MD, DM, Student, Department of Immunology; N.K. Garg, MD, DM, DNB, Professor; N. Sinha, MD, DM, Professor, Head, Department of Cardiology; S. Nityanand, MD, PhD, Professor, Head, Department of Hematology. *The first 2 authors contributed equally to the work. Address reprint requests to Dr. S. Nityanand, Department of Hematology, SGPGIMS, Raebareli Road, Lucknow-226014, India. E-mail: soniya@sgpgi.ac.in Accepted for publication April 14, 2008. |
