|
|
 |
|
|
|
|
 |
Dietary and Lifestyle Changes Associated with High Prevalence of Hyperuricemia and Gout in the Shandong Coastal Cities of Eastern China
ZHIMIN MIAO, CHANGGUI LI, YING CHEN, SHIHUA ZHAO, YANGANG WANG, ZHONGCHAO WANG, XINYAN CHEN, FENG XU, FANG WANG, RUIXIA SUN, JIANXIA HU, WEI SONG, SHENGLI YAN, and CONG-YI WANG
ABSTRACT. Methods. Data collected from 5,003 subjects randomly recruited from 5 coastal cities (Qingdao, Rizhao, Yantai, Weihai, and Dongying) of Shandong province in Eastern China were analyzed. Results. Overall, the prevalence for hyperuricemia and gout in the studied populations was 13.19% and 1.14%, respectively. The prevalence was significantly higher in men as compared to women (18.32% vs 8.56% for hyperuricemia, 1.94% vs 0.42% for gout). Hyperuricemia was more common in men over age 30 and in women over age 50. A significant steady increase for the prevalence was noted as compared to the previous published data. Urban residents showed much higher prevalence of hyperuricemia as compared to rural residents (14.9% vs 10.1%, p = 0.004). Similarly, higher prevalence was noted in the developed city compared to the less developed city (18.02 vs 5.3%). These discrepancies were highly correlated with economic development as manifested by the increase of daily consumption of meat and seafood. Additionally, alcohol, overweight or obesity, hypertension, and abnormal triglycerides were highly associated with higher prevalence of hyperuricemia. Moreover, hyperuricemia is likely a risk factor for the development of diabetes mellitus. Conclusion. There was a remarkable increase for the prevalence of hyperuricemia and gout, which is highly correlated with the development of the economy as manifested by dietary and lifestyle changes. (First Release July 15 2008; J Rheumatol 2008;35:1859–64) Key Indexing Terms:
GOUT From the Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao, China; and the Center for Biotechnology and Genomic Medicine and Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA. Supported by grants from the National Science Foundation of China (NSFC: 30470821 to Z. Miao) and NIH/NIDDK (DK074957 to C-Y. Wang). Z. Miao, MD; C. Li, MD; Y. Chen, MD; S. Zhao, MD; Y. Wang, MD; Z. Wang, MD; X. Chen, MD; F. Xu, MD; F. Wang, MD; R. Sun, MD; J. Hu, MD; W. Song, MD; S. Yan, MD, Department of Endocrinology, Medical School Hospital of Qingdao University; C-Y. Wang, MD, Center for Biotechnology and Genomic Medicine and Department of Pathology, Medical College of Georgia. Drs. Miao and Li contributed equally to this work. Address reprint requests to Dr. S. Yan, Department of Endocrinology, Medical School Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, PR China, E-mail: yansl2001@suhu.com; and Dr. C-Y. Wang, Center for Biotechnology and Genomic Medicine and Department of Pathology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, E-mail: cwang@mcg.edu Accepted for publication April 4, 2008. |
