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Case Report


Successful Treatment of Severe Behçet's Disease with Infliximab in an Italian Olympic Athlete

IGNAZIO OLIVIERI, LOREDANA LATANZA, SEBASTIANO SIRINGO, GIOVANNI PERUZ, and VALENTINA DI IORIO

ABSTRACT. An Italian Olympic athlete with a severe form of Behçet's disease was given infliximab. He had oral aphthosis, papulopustular and follicular lesions, and a bilateral cystoid macular edema. After the first 3 infusions, the mucocutaneous lesions disappeared and cystoid macular edema was much improved. Cyclosporine was stopped and the prednisone dose was progressively tapered until the cystoid macular edema disappeared. (J Rheumatol 2008;35:930-2)

Key Indexing Terms:

BEHÇET'S DISEASE
INFLIXIMAB
ANTI-TUMOR NECROSIS FACTOR-a INHIBITORS


From the Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza and Matera; Service of Ocular Immunopathology, Department of Ophthalmology, A. Cardarelli Hospital, Naples; and Gastrointestinal Unit, Garibaldi Hospital, Catania, Italy.

I. Olivieri, MD, Consultant, Director; G. Peruz, MD, Researcher, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera; L. Latanza, MD, Senior Registrar; V. Di Iorio, MD, Research Fellow, Service of Ocular Immunopathology, Department of Ophthalmology, A. Cardarelli Hospital; S. Siringo, MD, Senior Registrar, Gastrointestinal Unit, Garibaldi Hospital.

Address reprint requests to Dr. I. Olivieri, Rheumatology Department of Lucania, Ospedale S. Carlo, Contrada Macchia Romana 85100, Potenza, Italy. E-mail: ignazioolivieri@tiscalinet.it

Accepted for publication November 14, 2007.




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