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Editorials

Telemedicine in Rheumatology

J. Lewtas .........1745

Bias in Its Coat of Many Colors

M. Boers .........1747

Imaging Damage: Scoring Versus Measuring

J.P. Edmonds, M.N.D. Lassere .........1749

Articles

Linkage and Association Analysis of Candidate Genes in Rheumatoid Arthritis
 
S. John, S. Eyre, A. Myerscough, et al .........1752

Tumor Necrosis Factor-a (TNF-a) Converting Enzyme Contributes to Production of TNF-a in Synovial Tissues from Patients with Rheumatoid Arthritis
 
S. Ohta, M. Harigai, M. Tanaka, et al .........1756

Interferon-g Enhances Interleukin 12 Production in Rheumatoid Synovial Cells via CD40-CD154 Dependent and Independent Pathways
 
M. Kitagawa, H. Suzuki, Y. Adachi, H. Nakamura, S. Yoshino, T. Sumida .........1764

Hepatocyte Growth Factor (HGF), HGF Activator, and c-Met in Synovial Tissues in Rheumatoid Arthritis and Osteoarthritis
 
M. Nagashima, J. Hasegawa, K. Kato, et al .........1772

Mature Form of Interleukin 18 Is Expressed in Rheumatoid Arthritis Synovial Tissue and Contributes to Interferon-g Production by Synovial T Cells
 
M. Tanaka, M. Harigai, Y. Kawaguchi, et al .........1779

TNF Promoter Polymorphisms in Patients with RA in Taiwan
 
J-H. Yen, C-J. Chen, W-C. Tsai, et al .........1788

Influence of Longterm Therapy with MTX and Low Dose Corticosteroids on Type 1 and Type 2 Cytokine Production in CD4+ and CD8+ T Lymphocytes of Patients with RA
 
A.J. Schuerwegh, J.F. van Offel, C.H. Bridts, W.J. Stevens, L.S. De Clerck .........1793

MTX Inhibits Rheumatoid Synovitis by Inducing Apoptosis
 
F. Nakazawa, H. Matsuno, K. Yudoh, et al .........1800

Influence of Sex, Age, and Menopausal State on the Course of Early RA
 
S. Kuiper, A.M. van Gestel, H.L. Swinkels, T.M. de Boo, J.A.P. da Silva, P.L.C.M. van Riel .........1809

The Level of Inflammation in RA Is Determined Early and Remains Stable over the Longterm Course of the Illness
 
F. Wolfe, T. Pincus .........1817

Reliability and Sensitivity of Joint Space Measurements in Hand Radiographs Using Computerized Image Analysis
 
S.J. Angwin, G. Heald, A. Lloyd, K. Howland, M. Davy, M.F. James .........1825

Comparison of Extracapsular Changes by MRI in Patients with RA and PMR
 
D. McGonagle, C. Pease, H.A. Marzo-Ortega, P.J. O'Connor, W. Gibbon, P. Emery .........1837

Comparison of Disability and Quality of Life in Rheumatoid and Psoriatic Arthritis
 
K.B. Sokoll, P.S. Helliwell .........1842

Anti-Agalactosyl IgG Antibodies in Sera from Patients with SSc
 
C. Nishijima, S. Sato, K. Takehara .........1847

Tight Skin Mouse Subcutaneous Hypertrophy Can Occur in the Absence of aß TCR-Bearing Lymphocytes
 
D.A. Oble, H-S. Teh .........1852

High Prevalence of Thoracic Vertebral Deformities and Discal Wedging in AS Patients with Hyperkyphosis
 
P. Geusens, D. Vosse, D.M.F.M. van der Heijde, et al .........1856

Total Hip Arthroplasty in AS: Outcome in 340 Patients
 
S. Sweeney, R. Gupta, G. Taylor, A. Calin .........1862

Association of MICA Alleles and HLA-B51 in Italian Patients with Behçet's Disease
 
C. Salvarani, L. Boiardi, V. Mantovani, et al .........1867

Complications of Knee Arthroscopy Performed by Rheumatologists
 
S.J. Wollaston, P. Brion, A. Kumar, D. Klashman, K.C. Kalunian .........1871

Chlamydial Nucleic Acids in Synovium in OA: What Are the Implications?
 
N. Olmez, G.F. Wang, Y. Li, H. Zhang, H.R. Schumacher .........1874

Bias in Uncontrolled Therapeutic Trials in Rheumatology Due to Selection of Populations with Extreme Characteristics
 
J.P.A. Ioannidis, F.B. Karassa .........1881

Previous Pain Experience in Women with FM and Inflammatory Arthritis and Nonpainful Controls
 
R. Pöyhiä, D. Da Costa, M-A. Fitzcharles .........1888

Effort Testing in Patients with FM and Disability Incentives
 
R.O. Gervais, A.S. Russell, P. Green, L.M. Allen III, R. Ferrari, S.D. Pieschl .........1892

Seasonal Symptom Severity in Patients with Rheumatic Diseases: A Study of 1424 Patients
 
D.J. Hawley, F. Wolfe, F.A. Lue, H. Moldofsky .........1900

An Evaluation of Telehealth in the Provision of Rheumatologic Consults to a Remote Area
 
P. Davis, R. Howard, P. Brockway .........1910

Pediatric Rheumatology

Expression of Galectins-1 and -3 Correlates with Defective Mononuclear Cell Apoptosis in Patients with JIA
 
M. Harjacek, S. Diaz-Cano, M. De Miguel, H. Wolfe, C.A. Maldonado, G.A. Rabinovich .........1914

Case Report

Hemarthrosis as Initial Presentation of Scurvy
 
A.L. Pangan, D.R. Robinson .........1923

Images in Rheumatology

Dynamic Videomicroscopy Evaluation of SF in Gout

R. De Angelis, W. Grassi .........1926

Cholesterol Crystals in Gouty Bursitis

A.G. Fam .........1928

Correspondence

Opioids for OA of the Hip and Knee: Which Opiods for Which Patients? B. Bannwarth .........1930

Reply P.M. Peloso .........1931

Clinical Improvement in OA P. Stratford, J. Wessel .........1932

Reply E. Ehrich, G. Davies, D. Watson, J. Bolognese, B. Seidenberg, N. Bellamy .........1932

A Multicase Family with Primary Sjögren's Syndrome J.M. Sabio, E. Milla, J. Jiménez-Alonso .........1932

Reply A.I. Bolstad .........1933

Catastrophic Antiphospholipid Syndrome: Need for a Reappraisal L. Olguin-Ortega, L. Barile-Fabris, L.R. Espinoza .........1934

Reply R.A. Asherson .........1934

Letters

Sigmoid Diverticular Abscess Perforation in 2 Patients with RA Treated with High Dose Corticosteroids. A Cautionary Tale D. Hutchinson, M. Lynch .........1935

Rhabdomyolysis and 3,4 Methylenedioxymethamphetamine in Rheumatological Practice F. Verdone .........1936

The Role of Colchicine in Helicobacter pylori Prevalence and Gastric Mucosal Changes in Behçet's Disease C. Pata, K. Konca, A. Yazar .........1938

Book Review

Principles of Molecular Rheumatology .........1938

Notices