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Quantitative Clinical Rheumatology Shouldn't Standard Rheumatology Clinical Care Be Evidence-Based Rather Than Eminence-Based, Eloquence-Based, or Elegance-Based?
 
T. Pincus, P. Tugwell .........1

The Challenge of Early Diagnosis in Ankylosing Spondylitis
 
F. O'Shea, D. Salonen, R. Inman .........5 →RELATED ARTICLE

Cartilage Is Held Together by Elastic Carbohydrate Strings. Implications in Osteoarthrosis
 
J.E. Scott, R.D. Wigley .........8

Articles

Predicting Physical Activity and General Health Perception Among Patients with RA
   
E. Eurenius, N. Brodin, S. Lindblad, C.H. Opava, and the PARA Study Group .........10

TNF-a Induces Vascular Endothelial Growth Factor-C Expression in Rheumatoid Synoviocytes
   
H-S. Cha, E-K. Bae, J-H. Koh, et al .........16

Overexpression of A₃ Adenosine Receptor in PBMC in RA: Involvement of NF-kB in Mediating Receptor Level
   
L. Madi, S. Cohen, A. Ochayin, S. Bar-Yehuda, F. Barer, P. Fishman .........20

Blockade of Vascular Endothelial Growth Factor Activity Suppresses Wear Debris-Induced Inflammatory Osteolysis
   
W. Ren, R. Zhang, D.C. Markel, et al .........27

Polymorphisms in the IL4 and IL4RA Genes in Colombian Patients with RA
   
O. Moreno, C.I. González, D.L. Saaibi, et al .........36

TNF-a Promoter –308 A/G Polymorphism and RA Susceptibility: A Metaanalysis
   
Y.H. Lee, J.D. Ji, G.G. Song .........43

Prognosis of 5-year Radiographic Erosions of the Wrist According to Early, Late, and Persistent Wrist Swelling or Tenderness in Patients with Early RA
   
R. Luukkainen, T. Sokka, H. Kautiainen, et al .........50

Patient Self-Administered Joint Tenderness Counts in RA Are Reliable and Responsive to Changes in Disease Activity
   
F. Figueroa, Y. Braun-Moscovici, D. Khanna, et al .........54

The Economic Burden of RA in a Developing Nation: Results from a One-Year Prospective Cohort Study in Thailand
   
M. Osiri, A. Maetzel, P. Tugwell .........57

A Comparative Study of Patient-Reported Functional Outcomes in Acute RA
   
J. Zochling, G. Stucki, E. Grill, J. Braun .........64

Atherosclerotic Vascular Events in a Single Large Lupus Cohort: Prevalence and Risk Factors
   
M.B. Urowitz, D. Ibañez, D.D. Gladman .........70

Effect of Severe Neuropsychiatric Manifestations on Short-term Damage in SLE
   
H.E. Fragoso-Loyo, J. Sánchez-Guerrero .........76

Anti-Thyroid Autoantibody-Associated Interface Dermatitis in Individuals with UCTD — An Unrecognized Subset of Autoimmune Disease?
   
W. Cheng, A.C. Gilliam, A. Castrovinci, M. Pazirandeh .........81

Elevated Gene Expression of Th1/Th2 Associated Transcription Factors Is Correlated with Disease Activity in Patients with SLE
   
L.C.W. Lit, C.K. Wong, E.K. Li, L.S. Tam, C.W.K. Lam, Y.M.D. Lo .........89

Occupational Exposure to Solvents and Gender-Related Risk of SSc: a Metaanalysis of Case-Control Studies
   
A. Kettaneh, O. Al Moufti, K.P. Tiev, et al .........97

Disease Subsets, ANA Profile, and Clinical Features in 127 French and 247 US Adult Patients with SSc
   
O.C. Meyer, N. Fertig, M. Lucas, N. Somogyi, T.A. Medsger Jr .........104

Color and Duplex Doppler Sonography to Detect Sacroiliitis and Spinal Inflammation in AS. Can This Method Reveal Response to Anti-TNF Therapy?
   
E. Ünlü, Ö.N. Pamuk, N. Çakιr .........110 →RELATED ARTICLE

RA and Spondyloarthropathies: Geographical Variations in Prevalence in France
   
C. Roux, A. Saraux, E. Le Bihan, et al .........117

The Modified Nail Psoriasis Severity Index: Validation of an Instrument to Assess Psoriatic Nail Involvement in Patients with PsA
   
S.E. Cassell, J.D. Bieber, P. Rich, et al .........123

Early Inflammatory Arthritis in the Rabbit: The Influence of Intraarticular and Systemic Corticosteroids on mRNA Levels in Connective Tissues of the Knee
   
A.S. Kydd, C.R. Reno, H.W. Tsao, D.A. Hart .........130

Prevalence of Depressive Symptoms in Postmenopausal Women with Low BMD and/or Prevalent Vertebral Fracture: Results from the Multiple Outcomes of Raloxifene Evaluation (MORE) Study
   
S.L. Silverman, W. Shen, M.E. Minshall, S. Xie, K.H. Moses .........140

Variations in Torsion of the Lower Limb in Japanese and Caucasians with and without Knee OA
   
K. Tamari, N.K. Briffa, P. Tinley, K. Aoyagi .........145

Effect of Therapeutic Exercise and Sleeping Neck Support on Patients with Chronic Neck Pain: A Randomized Clinical Trial
   
A. Helewa, C.H. Goldsmith, H.A. Smythe, P. Lee, K. Obright, L. Stitt .........151

Is Self-Reported Improvement in OA Pain and Disability Reflected in Objective Measures?
   
S.R. Johnson, A. Archibald, A.M. Davis, E. Badley, J.G. Wright, G.A. Hawker .........159

Direct and Indirect Costs of OA in Singapore: A Comparative Study Among Multiethnic Asian Patients with OA
   
F. Xie, J. Thumboo, K.Y. Fong, et al .........165

Prevalence of Knee Symptoms and Radiographic and Symptomatic Knee OA in African Americans and Caucasians: The Johnston County Osteoarthritis Project
   
J.M. Jordan, C.G. Helmick, J.B. Renner, et al .........172

A Longitudinal Study of the Association Between Knee Alignment and Change in Cartilage Volume and Chondral Defects in a Largely Non-Osteoarthritic Population
   
G. Zhai, C. Ding, F. Cicuttini, G. Jones .........181

A Randomized Controlled Trial of the Reciprocating Procedure Device for IA Injection of Corticosteroid
   
A.D. Bankhurst, S.E. Nunez, H.T. Draeger, S.C. Kettwich, L.G. Kettwich, W.L. Sibbitt Jr .........187

Widespread Pain Following Whiplash-Associated Disorders: Incidence, Course, and Risk Factors
   
L.W. Holm, L.J. Carroll, J.D. Cassidy, E. Skillgate, A. Ahlbom .........193

Increased Cancer Risk in Patients Referred to Hospital with Suspected FM
   
L. Dreyer, L. Mellemkjaer, S. Kendall, B. Jensen, B. Danneskiold-Samsøe, H. Bliddal .........201

Musculoskeletal Pain in Malaysia: A COPCORD Survey
   
K. Veerapen, R.D. Wigley, H. Valkenburg .........207

Meeting Report GRAPPA — Group for Research and Assessment of Psoriasis and Psoriatic Arthritis, Stockholm, May/June 2006
 
P.S. Helliwell .........214

OGRYZLO RESEARCH DAY, UNIVERSITY OF TORONTO DIVISION OF RHEUMATOLOGY
Keynote Address Heart Disease in Rheumatoid Arthritis: Changing the Paradigm of Systemic Inflammatory Disorders
 
S.E. Gabriel .........220

Pediatric Rheumatology

Establishment of a Pilot Pediatric Registry for Chronic Vasculitis Is Both Essential and Feasible: A Childhood Arthritis and Rheumatology Alliance (CARRA) Survey
   
N.M.R. Wilkinson, J. Page, A.G. Uribe, V. Espinosa, D.A. Cabral .........224

Images in Rheumatology

Rheumatoid Nodule of the Extensor Tendons of the Lower Extremity
 
D.J. Donegan, J.N. Daniel .........227

Cholesterol Crystal Embolism in a Patient with Suspected Vasculitis
 
I. Sari, U. Pabuccuoglu, N. Akkoc .........229

Carotidynia in Takayasu Arteritis
 
W.A. Schmidt, E. Seipelt, A. Krause, D. Wernicke .........231

Correspondence

Patient's Ethnicity and Use of Therapies in RA

A.O. Adebajo, C. Mitchell .........233

Reply

D.C. Ang, H.E. Paulus, J.S. Louie .........233

JIA Classification Criteria: Loopholes and Diagnosis Software

E.M. Behrens, T. Beukelman, R.Q. Cron .........234

Reply

R. Merino, J. De Inocencio, J. García-Consuegra .........234

Carcinomas in Patients with SLE

M.S. Panchovska, L.I. Sapundzhiev, P.A. Atanasova .........235

Reply

S. Bernatsky, R. Ramsey-Goldman, A. Clarke .........235

Neurological Complications of Infliximab

J.C.P. Roos, A.J.K. Ostor .........236

Comment

M.G. Tektonidou .........237

Reply

D.W. Zochodne, L.O. Martin, J. Jarand, C. Voll .........237

Interstitial Pneumonitis and Anti-TNF-a Therapy

J.C.P. Roos, E.R. Chilvers, A.J.K. Ostor .........238

Reply

E. Villeneuve, A. St-Pierre, B. Haraoui .........238

Adalimumab-Associated Multiple Sclerosis

L. Bensouda-Grimaldi, D. Mulleman, J-P. Valat, E. Autret-Leca .........239

Reply

É. Toussirot .........240

Letter

Macrophage Activation Syndrome After Etanercept Treatment

C. Sandhu, A. Chesney, E. Piliotis, R. Buckstein, S. Koren .........241

Meetings in Rheumatology