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Editorials

Improving Outcomes in Rheumatoid Arthritis: What Determines Decisions to Change Ineffective Therapy?

T. Sokka, H. Mäkinen.........1213

The Predictive Power of Anti-Cyclic Citrullinated Peptide Antibodies: Window into Understanding Gene/Environment/Immunity Interactions

W. Lee, M.H. Weisman.........1216

Further Evidence for Insufficient Hypothalamic-Pituitary-Glandular Axes in Polymyalgia Rheumatica

R.H. Straub, M. Cutolo.........1219

Outcome in Small-Vessel Systemic Vasculitis

R.A. Luqmani, O. Flossmann.........1224

Towards International Guidelines for the Management of Psoriatic Arthritis

D.D. Gladman, P.J. Mease.........1228

Articles

COX-2 Genotype and RA

K.H. Lee, H-S. Kim, A. El-Sohemy, M.C. Cornelis, W-S. Uhm, S-C. Bae.........1231

SLC22A4, RUNX1, and SUMO4 Polymorphisms Are Not Associated with RA: A Case-Control Study in a Spanish Population

G. Orozco, E. Sánchez, M.A. González-Gay, et al.........1235

The Role of Anti-CCP Antibodies in Predicting Progression of Palindromic Rheumatism to RA

A.S. Russell, A. Devani, W.P. Maksymowych.........1240

Which Variables Best Predict Change in RA Therapy in Daily Clinical Practice?

M. Soubrier, D. Zerkak, L. Gossec, X. Ayral, C. Roux, M. Dougados .........1243

Factors Associated with Permanent Work Disability in Mexican Patients with RA. A Case-Control Study

J. Morales-Romero, L. Gonzalez-Lopez, A. Celis, B.E. Rodríguez-Arreola, C.E. Cabrera-Pivaral, J.I. Gamez-Nava .........1247

ILD in Patients with RA: Comparison with Cryptogenic Fibrosing Alveolitis over 5 Years

A.B. Rajasekaran, D. Shovlin, V. Saravanan, P. Lord, C. Kelly.........1250

The Frequency and Distribution of Minocycline Induced Hyperpigmentation in a RA Population

G. Roberts, H.A. Capell .........1254

Most Rheumatologists Are Conservative in Active RA Despite MTX Therapy: Results of the PRISME Survey

A. Saraux, V. Devauchelle-Pensec, L. Engerran, R-M. Flipo .........1258

Cost-Effectiveness Analysis of MTHFR Polymorphism Screening by PCR in Korean Patients with RA Receiving MTX

S-K. Kim, J-B. Jun, A. El-Sohemy, S-C. Bae.........1266

Dietary Caffeine Intake Does Not Affect MTX Efficacy in Patients with RA

E. Benito-Garcia, J.E. Heller, L.B. Chibnik, et al.........1275

Dimensions of Fatigue in SLE: Relationship to Disease Status and Behavioral and Psychosocial Factors

D. Da Costa, M. Dritsa, S. Bernatsky, et al .........1282

Comparative Analysis of Autoantibodies Against a-Fodrin in Serum, Tear Fluid, and Saliva from Patients with SS

S. Yavuz, E. Toker, M. Bicakcigil, G. Mumcu, S. Cakir .........1289

Low Serum Levels of DHEAS in Untreated Polymyalgia Rheumatica/Giant Cell Arteritis

J. Narváez, B. Bernad, C. Diaz Torné, et al.........1293

Outcome and Prognostic Factors During the Course of Primary Small-Vessel Vasculitides

L. Pavone, C. Grasselli, E. Chierici, et al .........1299

Management of Infusion Reactions to Infliximab in Patients with RA or SpA: Experience from an Immunotherapy Unit of Rheumatology

T. Lequerré, O. Vittecoq, N. Klemmer, et al .........1307

Nail and Distal Interphalangeal Joint in PsA

R. Scarpa, E. Soscia, R. Peluso, et al.........1315

Prostaglandin Production by Human Osteoclasts in Culture

J.A. Hackett, H. Allard-Chamard, P. Sarrazin, et al .........1320

Short-term Gene Expression Changes in Cartilage Explants Stimulated with IL-1ß plus Glucosamine and Chondroitin Sulfate

P-S. Chan, J.P. Caron, M.W. Orth.........1329

Recent Diuretic Use and the Risk of Recurrent Gout Attacks: The Online Case-Crossover Gout Study

D.J. Hunter, M. York, C.E. Chaisson, R. Woods, J. Niu, Y. Zhang.........1341

The Prevalence of Hyperuricemia in a Population of the Coastal City of Qingdao, China

H. Nan, Q. Qiao, Y. Dong, et al.........1346

Systematic Review of the Efficacy and Safety of Shock Wave Therapy for Lateral Elbow Pain

R. Buchbinder, S.E. Green, J.M. Youd, W.J.J. Assendelft, L. Barnsley, N. Smidt.........1351

Chemotherapy-Related Arthropathy

M-J. Kim, Y-M. Ye, H-S. Park, C-H. Suh.........1364

Pediatric Rheumatology

Functioning and Preferences for Improvement of Health Among Patients with JIA in Early Adulthood Using the WHO ICF Model

M. Arkela-Kautiainen, J. Haapasaari, H. Kautiainen, et al .........1369

Epidemiology of JIA in Alsace, France

S. Danner, C. Sordet, J. Terzic, et al .........1377

Radiographic and Clinical Outcome in Early JRA and JSpA: A 3-Year Prospective Study

A.M. Selvaag, B. Flatø, K. Dale, et al .........1382

Enzyme Elevation in Patients with JDM and Steroid Myopathy

M.Y. Naim, A.M. Reed .........1392

Epitope Mapping of Anti-a-Fodrin Autoantibody in Juvenile SS: Difference in Major Epitopes Between Primary and Secondary Cases

R. Shiari, I. Kobayashi, N. Toita, et al.........1395

Tribute and Reflection William Watson Buchanan, MD, FRCP, FRCPC, 1930-2006

P. Lee.........1401

Meeting Report Cardiovascular Effects of Selective COX-2 Inhibition: Is There a Class Effect? The International COX-2 Study Group

L.J. Crofford, M.D. Breyer, C.V. Strand, et al .........1403

Case Reports

Haverhill Fever with Spine Involvement

H. Abdulaziz, C. Touchie, B. Toye, J. Karsh.........1409

Anti-TNF-a-Induced Psoriasis

I. Sari, S. Akar, M. Birlik, B. Sis, F. Onen, N. Akkoc.........1411

Images in Rheumatology

Clinical Images: Bazin's Disease (Erythema Induratum)

M. Al-Mashaleh, D. Packham, N. Manolios.........1415

Spontaneous Osteonecrosis of the Knee

J.Y. Kim, D.R. Finger.........1416

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): Systematic Review of Treatments for PsA

Systematic Review of Treatments for PsA: An Evidence Based Approach and Basis for Treatment Guidelines

A.F. Kavanaugh, C.T. Ritchlin, the GRAPPA Treatment Guideline Committee.........1417

Therapies for Peripheral Joint Disease in PsA

E.R. Soriano, N.J. McHugh.........1422

Therapies for Axial Disease in PsA

P. Nash.........1431

Therapies for Psoriatic Enthesopathy

C.T. Ritchlin.........1435

Therapies for Dactylitis in PsA

P.S. Helliwell.........1439

Conventional Systemic Agents for Psoriasis

B.E. Strober, K. Siu, K. Menon.........1442

Biologic Therapies for Psoriasis

W-H. Boehncke, J. Prinz, A.B. Gottlieb.........1447

Therapies for Psoriatic Nail Disease

S. Cassell, A.F. Kavanaugh.........1452

Letters

Demyelinating Disease in a Patient with PsA and Family History of Multiple Sclerosis Treated with Infliximab

T. Ruiz-Jimeno, A. Carvajal, C. Mata, E. Aurrecoechea.........1457

Giant Cell Arteritis -- The Methotrexate Debate Revisited

D. Rimar, M. Rozenbaum, D. Zisman, et al.........1458

Book Reviews

A Primer on Musculoskeletal Examination.........1459

Occupational Musculoskeletal Disorders.........1460

Correction.........1460

Meetings in Rheumatology