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VOLUME 29: NO. 9 OCTOBER 2002

Editorials

Significance of Increased Circulating Proteasome in Autoimmune Disease

J.D. Mountz .........2027

Methotrexate: Vital New Information About a Middle Aged Drug

E.H. Giannini .........2031

Rheumatoid Factors: What Do They Tell Us?

M.M. Newkirk .........2034

Rheumatoid Arthritis: Time for Trials of Therapeutic Targets

J. Edmonds, M. Lassere .........2041

Articles

Circulating Proteasomes Are Markers of Cell Damage and Immunologic Activity in Autoimmune Diseases
 
K. Egerer, U. Kuckelkorn, P.E. Rudolph, et al .........2045

Anti-Sa Sera from Patients with RA Contain at Least 2 Different Subpopulations of Anti-Sa Antibodies
 
M. Escalona, F.J. López-Longo, C.M. González, et al .........2053

Enhanced Local Production of Osteopontin in Rheumatoid Joints
 
S. Ohshima, N. Yamaguchi, K. Nishioka, et al .........2061

Clinical Usefulness of Genetic Information for Predicting Radiographic Damage in RA
 
J.J. Chen, H. Mu, Y. Jiang, M-C. King, G. Thomson, L.A. Criswell .........2068

RF and Antibodies to Cyclic Citrullinated Peptide Differentiate RA from Undifferentiated Polyarthritis in Patients with Early Arthritis
 
A.L.M.A. Jansen, I.E. van der Horst-Bruinsma, D. van Schaardenburg, R.J. van de Stadt, M.H.M.T. de Koning, B.A.C. Dijkmans .........2074

Combination Therapy with MTX and HCQ for RA Increases Exposure to MTX
 
S.J. Carmichael, J. Beal, R.O. Day, S.E. Tett .........2077

The MTX Therapeutic Response in RA
 
M. Ortendahl, T. Holmes, J.D. Schettler, J.F. Fries .........2084

Longitudinal Measurement of MTX Liver Concentrations Do Not Correlate with Liver Damage, Clinical Efficacy, or Toxicity During a 3.5 Year Double Blind Study in RA
 
N.H. Fathi, F. Mitros, J. Hoffman, et al .........2092

"5D" Outcome in 52 Patients with RA Surviving 20 Years After Initial Disease Modifying Antirheumatic Drug Therapy
 
H. Capell, D. McCarey, R. Madhok, R. Hampson .........2099

Production of Thromboxane A2 and PGI2 Affected by Interaction of Heat Aggregated IgG, Endothelial Cells, and Platelets in Lupus Nephritis
 
N. Kaneko, J-I. Masuyama, H. Nara, et al .........2106

VH4-34 Encoded Antibody in SLE: Effect of Isotype
 
N.M. Bhat, L.M. Lee, R.F. van Vollenhoven, N.N.H. Teng, M.M. Bieber .........2114

Effect of a Culturally Sensitive Cholesterol Lowering Diet Program on Lipid and Lipoproteins, Body Weight, Nutrient Intakes, and Quality of Life in Patients with SLE
 
M. Shah, A. Kavanaugh, Y. Coyle, B. Adams-Huet, P.E. Lipsky .........2122

Predictors of Sustained Amenorrhea from Pulsed IV Cyclophosphamide in Premenopausal Women with SLE
 
J.P.A. Ioannidis, G.E. Katsifis, A.G. Tzioufas, H.M. Moutsopoulos .........2129

Serum Cytokine Levels and Type 1 and Type 2 Intracellular T Cell Cytokine Profiles in MCTD
 
E. Bodolay, M. Aleksza, P. Antal-Szalmás, et al .........2136

No Increased Frequency of Malignant Neoplasms in PMR and TA. A Prospective Longitudinal Study of 398 Cases and Matched Population Controls
 
G. Myklebust, T. Wilsgaard, B.K. Jacobsen, J.T. Gran .........2143

Mannose-Binding Lectin Variant Alleles and HLA-DR4 Alleles Are Associated with GCA
 
S. Jacobsen, B. Baslund, H.O. Madsen, N. Tvede, A. Svejgaard, P. Garred .........2148

ReA and Other Sequelae Following Sporadic S. typhimurium Infection in British Columbia, Canada: A Case Control Study
 
J.A. Buxton, M. Fyfe, S. Berger, M.B. Cox, K.A. Northcott, and the Multiprovincial S. typhimurium Case Control Study Group .........2154

Clues to Pathogenesis of SpA Derived from SF Mononuclear Cell Gene Expression Profiles
 
J. Gu, M. Rihl, E. Märker-Hermann, et al .........2159

NO Induced Cell Death in Human Osteoarthritic Synoviocytes Is Mediated by Tyrosine Kinase Activation and Hydrogen Peroxide and/or Superoxide Formation
 
D.V. Jovanovic, F. Mineau, K. Notoya, P. Reboul, J. Martel-Pelletier, J-P. Pelletier .........2165

Gene Marking in Adeno-Associated Virus Vector Infected Periosteum Derived Cells for Cartilage Repair
 
N. Kobayashi, T. Koshino, M. Uesugi, et al .........2176

Accuracy of Self-Reported Healthcare Use in Patients with OA
 
T.A. Cronan, H.R. Walen .........2181

Hip Muscle Strength and Muscle Cross Sectional Area in Men with and without Hip OA
 
M.H. Arokoski, J.P.A. Arokoski, M. Haara, et al .........2185

A Comparison of Once-Daily Tramadol with Normal Release Tramadol in the Treatment of Pain in OA
 
L. Adler, C. McDonald, C. O'Brien, M. Wilson .........2196

Effects of Treatment with Ibandronate on Bone Mass, Architecture, Biomechanical Properties, and Bone Concentration of Ibandronate in Ovariectomized Aged Rats
 
F. Bauss, S. Lalla, R. Endele, L.A. Hothorn .........2200

Ultrasound Guided Versus Conventional Joint and Soft Tissue Fluid Aspiration in Rheumatology Practice: A Pilot Study
 
P.V. Balint, D. Kane, J. Hunter, I.B. McInnes, M. Field, R.D. Sturrock .........2209

Pediatric Rheumatology

Frequency of Abnormal Hand and Wrist Radiographs at Time of Diagnosis of Polyarticular JRA
 
T. Mason, A.M. Reed, A.M. Nelson, et al .........2214

Expression of Melanoma Antigen Gene by Cells from Inflamed Joints in JRA
 
D.K. McCurdy, L-Q. Tai, K.L. Imfeld, M. Schwartz, F. Zaldivar, M.A. Berman .........2219

Association of Low Bone Mass with Vitamin D Receptor Gene and Calcitonin Receptor Gene Polymorphisms in JIA
 
L. Masi, R. Cimaz, G. Simonini, et al .........2225

Case Reports

RA After 9 Years of HIV Infection: Possible Contribution of Tritherapy
 
J. Wegrzyn, J-M. Livrozet, J-L. Touraine, P. Miossec .........2232

Images in Rheumatology

Cystic Lung Disease in SS

O. Hubscher, R. Re, R. Iotti .........2235

Tribute to Barbara Ansell, 1923-2001

J.G. Schaller .........2237

Correspondence

Identification of Radiologic Healing Phenomena in Patients with RA J.T. Sharp .........2239

Reply R. Rau .........2239

How Many Angels Could Dance on the Head of a Pin? G.E. Ehrlich .........2239

Reply R. Klein, P.A. Berg .........2240

Reply E. Werle, W. Eich .........2240

Polymorphism in the MMP-1 Promoter Gene and Severity of RA M. Massarotti, A. Marchesoni, M.L. Biondi, B. Marasini .........2241

Reply A. Constantin, V. Lauwers-Cancès, A. Cambon-Thomsen, A. Cantagrel .........2241

Dermatomyositis with Normal Creatine Kinase and Elevated Aldolase Levels U. Mercado .........2242

Reply J.D. Carter, J. Valeriano, F.B. Vasey .........2242

Chronic Nonmalignant Pain D.A. Fishbain .........2243

Reply A. Mailis, K. Nicholson .........2243

Letters

Deflazacort in GCA J-P. Devogelaer, C. Gennari .........2244

Manganese Superoxide Dismutase, Glutathione Peroxidase, and Total Radical Trapping Antioxidant Capacity in Active RA M.E. De Leo, A. Tranghese, M. Passantino, et al .........2245

Influence of Work Related Psychosocial Factors and Psychological Distress on Regional Musculoskeletal Pain D.A. Fishbain .........2246

Book Reviews

Diagnosis of Bone and Joint Disorders .........2247

Vasculitis .........2247

Textbook of Pediatric Rheumatology .........2247

Classic Papers in Rheumatology .........2248

Principles of Bone Biology .........2248

Correction

Abstracts of Podium Presentations, Canadian Rheumatology Association Meeting, February 20-23, 2002 .........2249

Notices



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