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VOLUME 29: NO. 9 OCTOBER 2002
Editorials
Significance of Increased Circulating Proteasome in Autoimmune Disease
 J.D. Mountz .........2027
Methotrexate: Vital New Information About a Middle Aged Drug
 E.H. Giannini .........2031
Rheumatoid Factors: What Do They Tell Us?
 M.M. Newkirk .........2034
Rheumatoid Arthritis: Time for Trials of Therapeutic Targets
 J. Edmonds, M. Lassere .........2041
Articles
Circulating Proteasomes Are Markers of Cell
Damage and Immunologic Activity in Autoimmune Diseases
 K. Egerer, U. Kuckelkorn, P.E. Rudolph, et al .........2045
Anti-Sa Sera from Patients with RA Contain at Least
2 Different Subpopulations of Anti-Sa Antibodies
 M. Escalona, F.J. López-Longo,
C.M. González, et al .........2053
Enhanced Local Production of Osteopontin in Rheumatoid Joints
 S. Ohshima, N. Yamaguchi, K. Nishioka, et al .........2061
Clinical Usefulness of Genetic Information for Predicting Radiographic Damage in RA
 J.J. Chen, H. Mu, Y. Jiang, M-C. King,
G. Thomson, L.A. Criswell .........2068
RF and Antibodies to Cyclic Citrullinated Peptide Differentiate RA from Undifferentiated Polyarthritis in Patients with Early Arthritis
 A.L.M.A. Jansen, I.E. van der Horst-Bruinsma,
D. van Schaardenburg, R.J. van de Stadt,
M.H.M.T. de Koning, B.A.C. Dijkmans .........2074
Combination Therapy with MTX and HCQ for RA Increases Exposure to MTX
 S.J. Carmichael, J. Beal, R.O. Day, S.E. Tett .........2077
The MTX Therapeutic Response in RA
 M. Ortendahl, T. Holmes, J.D. Schettler,
J.F. Fries .........2084
Longitudinal Measurement of MTX Liver Concentrations Do Not Correlate with Liver Damage, Clinical Efficacy, or Toxicity During a 3.5 Year Double Blind Study in RA
 N.H. Fathi, F. Mitros, J. Hoffman, et al .........2092
"5D" Outcome in 52 Patients with RA Surviving 20 Years After Initial Disease Modifying Antirheumatic Drug Therapy
 H. Capell, D. McCarey, R. Madhok, R. Hampson .........2099
Production of Thromboxane A2 and PGI2 Affected
by Interaction of Heat Aggregated IgG, Endothelial Cells, and Platelets in Lupus Nephritis
 N. Kaneko, J-I. Masuyama, H. Nara, et al .........2106
VH4-34 Encoded Antibody in SLE: Effect of Isotype
 N.M. Bhat, L.M. Lee, R.F. van Vollenhoven,
N.N.H. Teng, M.M. Bieber .........2114
Effect of a Culturally Sensitive Cholesterol
Lowering Diet Program on Lipid and Lipoproteins, Body Weight, Nutrient Intakes, and Quality of
Life in Patients with SLE
 M. Shah, A. Kavanaugh, Y. Coyle, B. Adams-Huet,
P.E. Lipsky .........2122
Predictors of Sustained Amenorrhea from Pulsed IV Cyclophosphamide in Premenopausal Women with SLE
 J.P.A. Ioannidis, G.E. Katsifis, A.G. Tzioufas,
H.M. Moutsopoulos .........2129
Serum Cytokine Levels and Type 1 and Type 2 Intracellular T Cell Cytokine Profiles in MCTD
 E. Bodolay, M. Aleksza, P. Antal-Szalmás, et al .........2136
No Increased Frequency of Malignant Neoplasms in PMR and TA. A Prospective Longitudinal Study of
398 Cases and Matched Population Controls
 G. Myklebust, T. Wilsgaard, B.K. Jacobsen,
J.T. Gran .........2143
Mannose-Binding Lectin Variant Alleles and HLA-DR4 Alleles Are Associated with GCA
 S. Jacobsen, B. Baslund, H.O. Madsen, N. Tvede,
A. Svejgaard, P. Garred .........2148
ReA and Other Sequelae Following Sporadic
S. typhimurium Infection in British Columbia, Canada:
A Case Control Study
 J.A. Buxton, M. Fyfe, S. Berger, M.B. Cox,
K.A. Northcott, and the Multiprovincial S. typhimurium
Case Control Study Group .........2154
Clues to Pathogenesis of SpA Derived from SF Mononuclear Cell Gene Expression Profiles
 J. Gu, M. Rihl, E. Märker-Hermann, et al .........2159
NO Induced Cell Death in Human Osteoarthritic Synoviocytes Is Mediated by Tyrosine Kinase Activation and Hydrogen Peroxide and/or Superoxide Formation
 D.V. Jovanovic, F. Mineau, K. Notoya,
P. Reboul, J. Martel-Pelletier, J-P. Pelletier .........2165
Gene Marking in Adeno-Associated Virus Vector Infected Periosteum Derived Cells for Cartilage Repair
 N. Kobayashi, T. Koshino, M. Uesugi, et al .........2176
Accuracy of Self-Reported Healthcare Use in
Patients with OA
 T.A. Cronan, H.R. Walen .........2181
Hip Muscle Strength and Muscle Cross Sectional
Area in Men with and without Hip OA
 M.H. Arokoski, J.P.A. Arokoski, M. Haara, et al .........2185
A Comparison of Once-Daily Tramadol with Normal Release Tramadol in the Treatment of Pain in OA
 L. Adler, C. McDonald, C. O'Brien, M. Wilson .........2196
Effects of Treatment with Ibandronate on Bone
Mass, Architecture, Biomechanical Properties,
and Bone Concentration of Ibandronate in Ovariectomized Aged Rats
 F. Bauss, S. Lalla, R. Endele, L.A. Hothorn .........2200
Ultrasound Guided Versus Conventional Joint and
Soft Tissue Fluid Aspiration in Rheumatology
Practice: A Pilot Study
 P.V. Balint, D. Kane, J. Hunter, I.B. McInnes,
M. Field, R.D. Sturrock .........2209
Pediatric Rheumatology
Frequency of Abnormal Hand and Wrist Radiographs
at Time of Diagnosis of Polyarticular JRA
 T. Mason, A.M. Reed, A.M. Nelson, et al .........2214
Expression of Melanoma Antigen Gene by Cells
from Inflamed Joints in JRA
 D.K. McCurdy, L-Q. Tai, K.L. Imfeld, M. Schwartz,
F. Zaldivar, M.A. Berman .........2219
Association of Low Bone Mass with Vitamin D Receptor Gene and Calcitonin Receptor Gene Polymorphisms in JIA
 L. Masi, R. Cimaz, G. Simonini, et al .........2225
Case Reports
RA After 9 Years of HIV Infection: Possible
Contribution of Tritherapy
 J. Wegrzyn,
J-M. Livrozet, J-L. Touraine, P. Miossec .........2232
Images in Rheumatology
Cystic Lung Disease in SS
 O. Hubscher, R. Re, R. Iotti .........2235
Tribute to Barbara Ansell, 1923-2001
 J.G. Schaller .........2237
Correspondence
Identification of Radiologic Healing Phenomena in Patients with RA J.T. Sharp .........2239
Reply R. Rau .........2239
How Many Angels Could Dance on the
Head of a Pin? G.E. Ehrlich .........2239
Reply R. Klein, P.A. Berg .........2240
Reply E. Werle, W. Eich .........2240
Polymorphism in the MMP-1 Promoter Gene and Severity of RA M. Massarotti, A. Marchesoni,
M.L. Biondi, B. Marasini .........2241
Reply A. Constantin, V. Lauwers-Cancès,
A. Cambon-Thomsen, A. Cantagrel .........2241
Dermatomyositis with Normal Creatine Kinase and Elevated Aldolase Levels U. Mercado .........2242
Reply J.D. Carter, J. Valeriano, F.B. Vasey .........2242
Chronic Nonmalignant Pain D.A. Fishbain .........2243
Reply A. Mailis, K. Nicholson .........2243
Letters
Deflazacort in GCA J-P. Devogelaer, C. Gennari .........2244
Manganese Superoxide Dismutase, Glutathione Peroxidase, and Total Radical Trapping Antioxidant Capacity in Active RA
M.E. De Leo, A. Tranghese, M. Passantino, et al .........2245
Influence of Work Related Psychosocial Factors
and Psychological Distress on Regional Musculoskeletal Pain D.A. Fishbain .........2246
Book Reviews
Diagnosis of Bone and Joint Disorders .........2247
Vasculitis .........2247
Textbook of Pediatric Rheumatology .........2247
Classic Papers in Rheumatology .........2248
Principles of Bone Biology .........2248
Correction
Abstracts of Podium Presentations,
Canadian Rheumatology Association Meeting,
February 20-23, 2002 .........2249
Notices
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