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VOLUME 32: SUPPLEMENT 74 MARCH 2005

Mechanism of Action of Tumor Necrosis Factor Antagonists

Canadian Expert Roundtable Meeting
Banff, Alberta, Canada
November 28-30, 2003

Introduction

E.C. Keystone, C.A. Dinarello ......... 1

Differentiating the Efficacy of TNF Inhibitors

B. Haraoui ......... 3

Safety of Biologic Therapies — An Update

E.C. Keystone ......... 8

Clinical Pharmacokinetics of TNF Antagonists

I. Nestorov ......... 13

Apoptosis in the Regulation of Immune Responses

M.J. Pinkoski, D.R. Green ......... 19

Infliximab Induced T Lymphocyte Apoptosis in Crohn's Disease

J.M.H. Van den Brande ......... 26

Effects of Infliximab Treatment on Rheumatoid Synovial Tissue

P.P. Tak ......... 31

Why Does TNF Targeted Therapy Reactivate Tuberculosis?

S. Ehlers ......... 35

Differences Between Anti-TNF-α Monoclonal Antibodies and Soluble TNF Receptors in Host Defense Impairment

C.A. Dinarello ......... 40